ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis.Frontiers in medicine · 2025Article
- Review
- Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling.International journal of molecular sciences · 2021Review
- Osteoporosis is associated with increased minor complications following single level ALIF and PSIF: an analysis of 7,004 patients.Journal of spine surgery (Hong Kong) · 2021Article
- Incidence and Risk of Venous Thromboembolism in Bisphosphonates and Selective Estrogen Receptor Modulators Treatment in Korea.Journal of Korean medical science · 2021Article
- Risk of venous thromboembolism in elderly patients with vertebral compression fracture: A population-based case-control study.Medicine · 2020Observational
- Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Dose-dependent Effects of Strontium Ranelate on Ovariectomy Rat Bone Marrow Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells.International journal of biological sciences · 2016Article
- Management of osteoporosis of the oldest old.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study.BMJ open · 2014Article
- A large prospective European cohort study of patients treated with strontium ranelate and followed up over 3 years.Rheumatology international · 2013Article
- A review on strontium ranelate long-term antifracture efficacy in the treatment of postmenopausal osteoporosis.Therapeutic advances in musculoskeletal disease · 2013Article
- Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis.Calcified tissue international · 2011Review
- Current and future treatment options in osteoporosis.European journal of clinical pharmacology · 2011Review
- Use of strontium as a treatment method for osteoporosis.Current osteoporosis reports · 2011Article
- Use of oral bisphosphonates and risk of venous thromboembolism: a population-based case-control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Spotlight on strontium ranelate: in postmenopausal osteoporosis.Drugs & aging · 2010Review
- Incidence of venous thromboembolism in users of strontium ranelate: an analysis of data from a prescription-event monitoring study in England.Drug safety · 2010Article
- Strontium Ranelate: Long-Term Efficacy against Vertebral, Nonvertebral and Hip Fractures in Patients with Postmenopausal Osteoporosis.Therapeutic advances in musculoskeletal disease · 2010Article
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6 authors.
Funding
Abstract
unlabelledIn a retrospective cohort study using the General Practice Research Database (GPRD), there was a greater association of venous thromboembolism (VTE) in osteoporotic than in non-osteoporotic female patients. No greater association was shown in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic female patients.
introductionWe explored the risk of VTE in usual practice in osteoporotic and non-osteoporotic women with and without anti-osteoporotic treatment.
methodsA retrospective study was conducted using the GPRD in the UK. The cohorts consisted of untreated osteoporotic women (N = 11,546), osteoporotic women treated with alendronate (N = 20,084), or strontium ranelate (N = 2,408), and a sample of non-osteoporotic women (N = 115,009). Cohorts were compared using a Cox proportional hazards regression model.
resultsThere was a significantly increased relative risk for VTE in untreated osteoporotic women versus non-osteoporotic women (annual incidence 5.6 and 3.2 per 1,000 patient-years, respectively; relative risk 1.75 [95% confidence interval (CI), 1.09-1.84]). Results were confirmed using adjusted models. The annual incidences of VTE in osteoporotic patients treated with strontium ranelate and alendronate were 7.0 and 7.2 per 1,000 patient-years, respectively, with no significant difference between untreated and treated patients whatever the treatment. Adjusted hazard ratios for treated versus untreated osteoporotic women were 1.09 (95% CI, 0.60-2.01) for strontium ranelate and 0.92 (95% CI, 0.63-1.33) for alendronate.
conclusionThis study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients.
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