ArticleThe review of diabetic studies : RDS2009
Histopathology of type 1 diabetes: old paradigms and new insights.
Article in The review of diabetic studies : RDS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Evaluation of distinct and similar pathological features between diabetes and Alzheimer's disease.EXCLI journal · 2026Review
- Deep Learning for Type 1 Diabetes Mellitus Diagnosis Using Infrared Quantum Cascade Laser Spectroscopy.Materials (Basel, Switzerland) · 2022Article
- Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas.Frontiers in endocrinology · 2021Article
- Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells.Microorganisms · 2020Review
- Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence.Diabetologia · 2019Article
- What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters.Journal of veterinary internal medicine · 2016Review
- Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.Immunology and cell biology · 2016Article
- Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients.Diabetologia · 2015Article
- NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription.American journal of physiology. Endocrinology and metabolism · 2014Article
- The changing landscape of type 1 diabetes: recent developments and future frontiers.Current diabetes reports · 2013Review
- Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.Diabetes · 2013Article
- Article
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.The Journal of experimental medicine · 2012Article
- Clinical potential of antigen-specific therapies in type 1 diabetes.The review of diabetic studies : RDS · 2012Review
- Virus infections in type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.The review of diabetic studies : RDS · 2012Review
- Intravital imaging of CTLs killing islet cells in diabetic mice.The Journal of clinical investigation · 2012Article
- Viruses and cytotoxic T lymphocytes in type 1 diabetes.Clinical reviews in allergy & immunology · 2011Review
- Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice.Clinical and experimental immunology · 2011Article
- Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes.Nature reviews. Drug discovery · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Although our knowledge on the various aspects of diabetes development in the NOD mouse model is substantial and keeps expanding at a dramatic pace, the dataset on histopathologic features of type 1 diabetes (T1D) in patients remains largely stagnant. Early work has established an array of common aspects that have become epitomic in the absence of new patient material. There is a growing consensus that an updated and more detailed view is required that challenges and expands our understanding. Comprehensive initiatives are currently ongoing to address these issues in pre-diabetic, recent onset and longstanding type 1 diabetic individuals, and some of the old data have been recently revisited. In this review article, we wish to provide an overview of where we stand today and how we can correlate the various cross-sectional studies from the past with contemporary models of the disease. We believe an enhanced understanding of the many histopathological particularities in patients as compared to animal models will ultimately lead, not only to more fundamental insights, but also to an improved ability to translate pre-clinical data from bench to bedside.
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