ArticleInternational journal of obesity (2005)2010
Microvascular dysfunction: a direct link among BMI, waist circumference and glucose homeostasis in young overweight/obese normoglycemic women?
Article in International journal of obesity (2005), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 25 citations in OpenAlex.
- Cortisol level after dexamethasone suppression test in patients with non-functioning adrenal incidentaloma is positively associated with the duration of reactive hyperemia response on microvascular bed.Journal of endocrinological investigation · 2021Article
- Acute Effects of Metformin and Vildagliptin after a Lipid-Rich Meal on Postprandial Microvascular Reactivity in Patients with Type 2 Diabetes and Obesity: A Randomized Trial.Journal of clinical medicine · 2020Article
- Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status.BioMed research international · 2018Article
- Microcirculation, Adiposity, and Traditional and Emerging Cardiovascular Risk Factors in Prepubertal Children.Journal of the Endocrine Society · 2017Article
- Anthropometric and Quality-of-Life Parameters in Acute Intermittent Porphyria Patients.Medicine · 2015Article
- Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: a principal component analysis approach.BMC cardiovascular disorders · 2012Article
- Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial.Nutrition & metabolism · 2011Article
- Organic grape juice intake improves functional capillary density and postocclusive reactive hyperemia in triathletes.Clinics (Sao Paulo, Brazil) · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCapillary recruitment is impaired in obesity (OB), possibly worsening glucose and insulin availability to target organs. In this study, we investigated whether functional microvascular parameters were correlated with clinical-anthropometrical data and whether these parameters would influence OB-related metabolic disorders, especially glucose homeostasis, in young overweight (OW)/obese women.
designCross-sectional clinical study of microvascular reactivity in young OW/obese women. SUBJECTS AND
methodsA total of 10 lean (23.1 + or - 3.2 years, body mass index (BMI) 22.3 + or - 1.6 kg m(-2)) and 42 OW/obese (24.9 + or - 3.5 years; BMI 34.5 + or - 5.7 (25.7-46.5) kg m(-2)) sedentary non-smoking women were evaluated. Lipid profile, fasting plasma glucose (PG), post-load PG (75 g-2 h), insulin, C-reactive protein, HOMA-IR (homeostasis model assessment for insulin resistance) index and anthropometric variables (weight, BMI, waist and hip circumferences, waist-to-hip ratio and blood pressure (BP)) were determined. Functional microvascular parameters (functional capillary density, red blood cell velocity at baseline and peak (RBCV(max)), and time taken to reach RBCV(max) (TRBCV(max)) during post-occlusive reactive hyperemia after 1 min arterial occlusion) were evaluated by nailfold videocapillaroscopy.
resultsThe time taken to reach RBCV(max) was significantly longer in OW/obese patients compared with control subjects (8.6 + or - 2.4 versus 5.7 + or - 1.1 s, P<0.001), and its delay was directly associated with adiposity levels, systolic BP and insulin resistance, and inversely related to high-density lipoprotein-cholesterol. Post-load PG could be correlated with TRBCV(max) (R = 0.48, P<0.05) and RBCV(max) (R = -0.29, P<0.05), and it was influenced by weight, waist circumference and TRBCV(max) (adjusted R(2) = 24%) as well.
conclusionsIn the investigated group of young OW/obese women, the direct correlation between post-load PG and TRBCV(max) links microvascular parameters with metabolic variables and suggests a key role for microcirculation in OB-related metabolic disorders.
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