ArticleGenetics2009
Efficient transposition of Tol2 in the mouse germline.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy.Experimental hematology & oncology · 2024Review
- Current strategies employed in the manipulation of gene expression for clinical purposes.Journal of translational medicine · 2022Review
- Murine allele and transgene symbols: ensuring unique, concise, and informative nomenclature.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications ofInternational journal of molecular sciences · 2021Review
- A native, highly active Tc1/mariner transposon from zebrafish (ZB) offers an efficient genetic manipulation tool for vertebrates.Nucleic acids research · 2021Article
- In vivo functional screening for systems-level integrative cancer genomics.Nature reviews. Cancer · 2020Review
- Preclinical and clinical advances in transposon-based gene therapy.Bioscience reports · 2017Review
- Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus.Scientific reports · 2017Article
- Zebrafish Genome Engineering Using the CRISPR-Cas9 System.Trends in genetics : TIG · 2016Review
- Active recombinant Tol2 transposase for gene transfer and gene discovery applications.Mobile DNA · 2016Article
- Physiology of the read-write genome.The Journal of physiology · 2014Review
- DNA transposon-based gene vehicles - scenes from an evolutionary drive.Journal of biomedical science · 2013Review
- Comparative analysis of the recently discovered hAT transposon TcBuster in human cells.PloS one · 2012Article
- Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis.Mobile DNA · 2011Article
- Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy.BMC biotechnology · 2011Article
- LINE-1 elements in structural variation and disease.Annual review of genomics and human genetics · 2011Review
- Harnessing transposons for cancer gene discovery.Nature reviews. Cancer · 2010Review
- Transposon transgenesis in Xenopus.Methods (San Diego, Calif.) · 2010Review
- Remobilization of Tol2 transposons in Xenopus tropicalis.BMC developmental biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Insertional mutagenesis screens play an integral part in the annotating of functional data for all sequenced genes in the postgenomic era. Chemical mutagenesis screens are highly efficient but identifying the causative gene can be a laborious task. Other mutagenesis platforms, such as transposable elements, have been successfully applied for insertional mutagenesis screens in both the mouse and rat. However, relatively low transposition efficiency has hampered their use as a high-throughput forward genetic mutagenesis screen. Here we report the first evidence of germline activity in the mouse using a naturally active DNA transposon derived from the medaka fish called Tol2, as an alternative system for high-throughput forward genetic mutagenesis screening tool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.