ArticleInfection and immunity2009
The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Secreted Aspartic Proteinases: Key Factors inInternational journal of molecular sciences · 2024Review
- More than Just Protein Degradation: The Regulatory Roles and Moonlighting Functions of Extracellular Proteases Produced by Fungi Pathogenic for Humans.Journal of fungi (Basel, Switzerland) · 2023Review
- From environmental adaptation to host survival: Attributes that mediate pathogenicity ofVirulence · 2022Article
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- The impact of episporic modification ofComputational and structural biotechnology journal · 2021Article
- An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation inGenetics · 2020Article
- A unique aspartyl protease gene expansion in Talaromyces marneffei plays a role in growth inside host phagocytes.Virulence · 2019Article
- Automated tracking of label-free cells with enhanced recognition of whole tracks.Scientific reports · 2019Article
- Proteomic Analysis of the Responses ofJournal of fungi (Basel, Switzerland) · 2019Article
- NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans.Scientific reports · 2017Article
- Aspartic Proteases and Major Cell Wall Components inFrontiers in cellular and infection microbiology · 2017Article
- Article
- In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans.Virulence · 2016Article
- The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.PLoS pathogens · 2016Article
- Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation.AMB Express · 2015Article
- Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.Nucleic acids research · 2015Article
- A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood.PLoS computational biology · 2014Article
- Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans.Journal of biomedical science · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human polymorphonuclear neutrophils (PMNs) play a major role in the immune defense against invasive Candida albicans infection. This fungal pathogen produces a set of aspartic proteases that directly contributes to virulence properties such as adhesion, tissue invasion, and immune evasion. We show here that, in contrast to other secreted proteases, the cell surface-associated isoform Sap9 has a major impact on the recognition of C. albicans by PMNs. SAP9 is required for the induction of PMN chemotaxis toward C. albicans filaments, an essential prerequisite of effective PMN activation. Furthermore, deletion of SAP9 leads to a mitigated release of reactive oxygen intermediates (ROI) in human PMNs and decreases C. albicans-induced apoptosis triggered by ROI formation. In confrontation assays, killing of a SAP9 deletion mutant is reduced in comparison to wild-type C. albicans. These data clearly implicate Sap9 protease activity in the initiation of protective innate immunity and suggest novel molecular mechanisms in C. albicans-host interaction leading to neutrophil activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.