ArticleProceedings of the National Academy of Sciences of the United States of America2009
Experience-dependent maturation of the glomerular microcircuit.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 68 citations in OpenAlex.
- Connexin 36-mediated gap junctions contribute to fine odour discrimination and late-phase excitation of mitral cells in the mouse olfactory bulb.The Journal of physiology · 2026Article
- Short-term synaptic dynamics in the ventrolateral and dorsomedial periaqueductal gray.bioRxiv : the preprint server for biology · 2025Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.PLoS biology · 2024Article
- Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.Advanced healthcare materials · 2022Review
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- GAP junctions: multifaceted regulators of neuronal differentiation.Tissue barriers · 2022Article
- A scalable assay for chemical preference of small freshwater fish.Frontiers in behavioral neuroscience · 2022Article
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Article
- The interplay between electrical and chemical synaptogenesis.Journal of neurophysiology · 2018Review
- Article
- Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network.The Journal of physiology · 2017Article
- Synchronous Infra-Slow Bursting in the Mouse Accessory Olfactory Bulb Emerge from Interplay between Intrinsic Neuronal Dynamics and Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Three-dimensional synaptic analyses of mitral cell and external tufted cell dendrites in rat olfactory bulb glomeruli.The Journal of comparative neurology · 2017Article
- Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Parallel processing of afferent olfactory sensory information.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Spontaneous and patterned activity, largely attributed to chemical transmission, shape the development of virtually all neural circuits. However, electrical transmission also has an important role in coordinated activity in the brain. In the olfactory bulb, gap junctions between apical dendrites of mitral cells increase excitability and synchronize firing within each glomerulus. We report here that the development of the glomerular microcircuit requires both sensory experience and connexin (Cx)36-mediated gap junctions. Coupling coefficients, which measure electrical coupling between mitral cell dendrites, were high in young mice, but decreased after postnatal day (P)10 because of a maturational increase in membrane conductance. Sensory deprivation, induced by unilateral naris occlusion at birth, slowed the morphological development of mitral cells and arrested the maturational changes in membrane conductance and coupling coefficients. As the coupling coefficients decreased in normal mice, a glutamate-mediated excitatory postsynaptic current (EPSC) between mitral cells emerged by P30. Although mitral-mitral EPSCs were generally unidirectional, they were not present in young adult Cx36(-/-) mice, suggesting that gap junctions are required for the development and/or function of the mature circuit. The experience-dependent transition from electrical transmission to combined chemical and electrical transmission provides a previously unappreciated mechanism that may tune the response properties of the glomerular microcircuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.