ArticleProceedings of the National Academy of Sciences of the United States of America2009
Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
- HMGB1 couples LEF1 to regulate B cell immunity.JCI insight · 2025Article
- Construction of a glycolysis-related diagnostic model for osteoarthritis through integrated bioinformatics analysis and machine learning.Journal of orthopaedic surgery and research · 2025Article
- Critical signaling molecules in the temporomandibular joint osteoarthritis under different magnitudes of mechanical stimulation.Frontiers in pharmacology · 2024Review
- Cartilage fragments combined with BMSCs-Derived exosomes can promote tendon-bone healing after ACL reconstruction.Materials today. Bio · 2023Article
- HMGB2 upregulation promotes the progression of hepatocellular carcinoma cells through the activation of ZEB1/vimentin axis.Journal of gastrointestinal oncology · 2023Article
- HMGB2 regulates the differentiation and stemness of exhausted CD8Nature communications · 2023Article
- Structure and Functions of HMGB2 Protein.International journal of molecular sciences · 2023Review
- Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3.Scientific reports · 2023Article
- MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway.European journal of histochemistry : EJH · 2022Article
- Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg-Calvé-Perthes Disease and Correlation With IL-6.JBMR plus · 2021Article
- High mobility group box 2 modulates the progression of osteosarcoma and is related with poor prognosis.Annals of translational medicine · 2020Article
- Review
- Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation.Nature communications · 2018Article
- HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles.Scientific reports · 2018Article
- Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis.Frontiers in physiology · 2018Review
- HMGB proteins and arthritis.Human cell · 2018Review
- Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Limb proportions show developmental plasticity in response to embryo movement.Scientific reports · 2017Article
- Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis.Osteoarthritis and cartilage · 2016Article
- Mesenchymal Stem Cells for Osteochondral Tissue Engineering.Methods in molecular biology (Clifton, N.J.) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The superficial zone (SZ) of articular cartilage is critical in maintaining tissue function and homeostasis and represents the site of the earliest changes in osteoarthritis. Mechanisms that regulate the unique phenotype of SZ chondrocytes and maintain SZ integrity are unknown. We recently demonstrated that expression of the chromatin protein high mobility group box (HMGB) protein 2 is restricted to the SZ in articular cartilage suggesting a transcriptional regulation involving HMGB2 in SZ. Here, we show that an interaction between HMGB2 and the Wnt/beta-catenin pathway regulates the maintenance of the SZ. We found that the Wnt/beta-catenin pathway is active specifically in the SZ in normal mouse knee joints and colocalizes with HMGB2. Both Wnt signaling and HMGB2 expression decrease with aging in mouse joints. Our molecular studies show that HMGB2 enhances the binding of Lef-1 to its target sequence and potentiates transcriptional activation of the Lef-1-beta-catenin complex. The HMG domain within HMGB2 is crucial for interaction with Lef-1, suggesting that both HMGB2 and HMGB1 may be involved in this function. Furthermore, conditional deletion of beta-catenin in cultured mouse chondrocytes induced apoptosis. These findings define a pathway where protein interactions of HMGB2 and Lef-1 enhance Wnt signaling and promote SZ chondrocyte survival. Loss of the HMGB2-Wnt signaling interaction is a new mechanism in aging-related cartilage pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.