ArticleProceedings of the National Academy of Sciences of the United States of America2009
Increased expression of Mg(2+) transport proteins enhances the survival of Salmonella enterica at high temperature.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
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- Pervasive Divergence in Protein Thermostability is Mediated by Both Structural Changes and Cellular Environments.Molecular biology and evolution · 2025Article
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- Inorganic Additive Improves the Survival of the Probiotic Lacticaseibacillus rhamnosus CRL1505 During Spray Drying, Rehydration, and Storage.Current microbiology · 2021Article
- Glucose Starvation, Magnesium Ion Starvation, and Bile Stress Assays.Bio-protocol · 2021Article
- Role of OB-Fold Protein YdeI in Stress Response and Virulence of Salmonella enterica Serovar Enteritidis.Journal of bacteriology · 2020Article
- RpoS-regulatedVirulence · 2020Article
- Enhancement of Thermal Resistance by Metal Ions in ThermotolerantFrontiers in microbiology · 2020Article
- The Temperature-Regulation ofFrontiers in microbiology · 2020Article
- Quantitative Proteomic Analyses of a Pathogenic Strain and Its Highly Passaged Attenuated Strain ofBioMed research international · 2019Article
- Analyzing Thermal Stability of Cell Membrane of Salmonella Using Time-Multiplexed Impedance Sensing.Biophysical journal · 2018Article
- Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness inFrontiers in microbiology · 2018Article
- Mg2+ regulates transcription of mgtA in Salmonella Typhimurium via translation of proline codons during synthesis of the MgtL peptide.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evaporation-induced stimulation of bacterial osmoregulation for electrical assessment of cell viability.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro.eLife · 2016Article
- Article
- Defect in the formation of 70S ribosomes caused by lack of ribosomal protein L34 can be suppressed by magnesium.Journal of bacteriology · 2014Article
- Assessment of the requirements for magnesium transporters in Bacillus subtilis.Journal of bacteriology · 2014Article
- Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system.Molecular microbiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mg(2+) homeostasis is important for Salmonella pathogenesis. In Salmonella enterica, the transcription of the mgtA gene, which encodes a Mg(2+) transporter, is regulated by a Mg(2+)-sensing riboswitch [Cromie MJ, Shi Y, Latifi T, Groisman EA (2006) Cell 125:71-84]. In a genetic analysis of the determinants of thermotolerance in S. enterica serovar Typhimurium, we isolated the chr-1 mutation that increased the resistance of exponential phase cells to killing by high temperature. This mutation is a single base change in the mgtA riboswitch that causes high-level constitutive expression of mgtA. We showed that another mgtA riboswitch mutation, DeltaUTR(re-100), which had been constructed by Cromie et al., also confers similar increased thermotolerance. Surprisingly, the chr-1 mutation is located at a position that would not be predicted to be important for the regulatory function of the riboswitch. We obtained physiological evidence suggesting that the chr-1 mutation increases the cytosolic free Mg(2+) concentration. High-level expression of the heterologous MgtE Mg(2+) transport protein of Bacillus subtilis also enhanced the thermotolerance of S. enterica. We hypothesize that increased Mg(2+) accumulation might enhance thermotolerance by protecting the integrity of proteins or membranes, by mitigating oxidative damage or acting as an inducer of thermoprotective functions.
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