ArticleProceedings of the National Academy of Sciences of the United States of America2009
Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 118 citations in OpenAlex.
- Age-related changes in calcium ion influx and efflux capacity of human dermal fibroblasts.Cell communication and signaling : CCS · 2026Article
- The signal that stimulates mammalian embryo development.Frontiers in cell and developmental biology · 2024Review
- Methods to Quantify the Dynamic Recycling of Plasma Membrane Channels.Bio-protocol · 2023Article
- Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.International journal of molecular sciences · 2022Review
- Control of STIM and Orai function by post-translational modifications.Cell calcium · 2022Review
- CaJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions.Cells · 2022Review
- NKD2 mediates stimulation-dependent ORAI1 trafficking to augment CaCell reports · 2021Article
- The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation.Cells · 2021Review
- Soluble αKlotho downregulates Orai1-mediated store-operated CaPflugers Archiv : European journal of physiology · 2021Article
- The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.Scientific reports · 2021Article
- More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins.International journal of molecular sciences · 2021Review
- Molecular Choreography and Structure of CaMembranes · 2020Review
- Modulators of calcium signalling at fertilization.Open biology · 2020Review
- Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Constitutive IPJournal of cell science · 2019Article
- The CCT chaperonin is a novel regulator of CaScience advances · 2018Article
- Calcium oscillations in fertilized pig oocytes are associated with repetitive interactions between STIM1 and ORAI1.Biology of reproduction · 2018Article
- Ion Channel Function During Oocyte Maturation and Fertilization.Frontiers in cell and developmental biology · 2018Review
- Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Store-operated Ca(2+) entry (SOCE) is a ubiquitous Ca(2+) influx pathway activated in response to depletion of intracellular Ca(2+) stores. SOCE is a primary modulator of intracellular Ca(2+) dynamics, which specify cellular responses. Interestingly, SOCE inactivates during M phase but the mechanisms involved remain unclear. SOCE is mediated by clustering of the ER Ca(2+) sensor STIM1 in response to Ca(2+) store depletion, leading to gating of the plasma membrane SOCE channel Orai1. Here we show that SOCE inactivation in meiosis is the result of internalization of Orai1 into an intracellular vesicular compartment and to the inability of STIM1 to cluster in response to store depletion. At rest, Orai1 continuously recycles between the cell membrane and an endosomal compartment. We further show that STIM1-STIM1 interactions are inhibited during meiosis, which appears to mediate the inability of STIM1 to form puncta following store depletion. In contrast, STIM1-Orai1 interactions remain functional during meiosis. Combined, the removal of Orai1 from the cell membrane and STIM1 clustering inhibition effectively uncouple store depletion from SOCE activation in meiosis. Although STIM1 is phosphorylated during meiosis, phosphomimetic and alanine substitution mutations do not modulate STIM1 clustering, arguing that phosphorylation does not mediate STIM1 clustering inhibition during meiosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.