ArticleProceedings of the National Academy of Sciences of the United States of America2009
Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Design and Characterization of a Transcriptional Repression Toolkit for Plants.ACS synthetic biology · 2024Article
- Limited Availability of General Co-Repressors Uncovered in an Overexpression Context during Wing Venation inGenes · 2020Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- Genome-wide errant targeting by Hairy.eLife · 2015Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- The unconserved groucho central region is essential for viability and modulates target gene specificity.PloS one · 2012Article
- The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo.Current biology : CB · 2011Article
- Long- and short-range transcriptional repressors induce distinct chromatin states on repressed genes.Current biology : CB · 2011Article
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
- Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density.PloS one · 2010Article
- Review
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2 authors.
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Abstract
Despite the pervasive roles for repressors in transcriptional control, the range of action of these proteins on cis regulatory elements remains poorly understood. Knirps has essential roles in patterning the Drosophila embryo by means of short-range repression, an activity that is essential for proper regulation of complex transcriptional control elements. Short-range repressors function in a local fashion to interfere with the activity of activators or basal promoters within approximately 100 bp. In contrast, long-range repressors such as Hairy act over distances >1 kb. The functional distinction between these two classes of repressors has been suggested to stem from the differential recruitment of the CtBP corepressor to short-range repressors and Groucho to long-range repressors. Contrary to this differential recruitment model, we report that Groucho is a functional part of the Knirps short-range repression complex. The corepressor interaction is mediated via an eh-1 like motif present in the N terminus and a conserved region present in the central portion of Knirps. We also show that this interaction is important for the CtBP-independent repression activity of Knirps and is required for regulation of even-skipped. Our study uncovers a previously uncharacterized interaction between proteins previously thought to function in distinct repression pathways, and indicates that the Groucho corepressor can be differentially harnessed to execute short- and long-range repression.
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