ArticleProceedings of the National Academy of Sciences of the United States of America2009
miR-145 directs intestinal maturation in zebrafish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 68 citations in OpenAlex.
- Zebrafish as a platform to evaluate the potential of lipidic nanoemulsions for gene therapy in cancer.Frontiers in pharmacology · 2022Article
- miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death.Physiological reports · 2021Article
- Conservation of Zebrafish MicroRNA-145 and Its Role during Neural Crest Cell Development.Genes · 2021Article
- MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.PLoS genetics · 2019Article
- Interplay Between MicroRNAs and Targeted Genes in Cellular Homeostasis of Adult Zebrafish (Current genomics · 2018Article
- Dual Functional Roles of Molecular Beacon as a MicroRNA Detector and Inhibitor.The Journal of biological chemistry · 2017Article
- Article
- Article
- Mesenchymal-epithelial interactions during digestive tract development and epithelial stem cell regeneration.Cellular and molecular life sciences : CMLS · 2015Review
- Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.Nucleic acids research · 2014Article
- Review
- Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- An α-smooth muscle actin (acta2/αsma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells.PloS one · 2014Article
- MicroRNAs in cardiac regeneration and cardiovascular disease.Science China. Life sciences · 2013Review
- The admiR-able advances in cardiovascular biology through the zebrafish model system.Cellular and molecular life sciences : CMLS · 2013Review
- Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish.PloS one · 2013Article
- Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription.PLoS genetics · 2012Article
- MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis.Nucleic acids research · 2012Article
- Interplays between gut microbiota and gene expression regulation by miRNAs.Frontiers in cellular and infection microbiology · 2012Article
- Reverse genetics screen in zebrafish identifies a role of miR-142a-3p in vascular development and integrity.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The rapid specification and differentiation of the embryonic zebrafish gut is essential to provide contractility for the digestion of food. The role of microRNAs in modulating gut epithelial or smooth muscle differentiation is currently not known. Here we show that the microRNA miR-145 is strongly expressed in zebrafish gut smooth muscle and regulates its development. Modulation of miR-145 levels results in gut smooth muscle and epithelium maturation defects. Loss of miR-145 results in defects of smooth muscle function as measured by decreased nitric oxide production but also leads to increased expression of the embryonic smooth muscle markers sm22alpha-b, nm-mhc-b, and smoothelin. Defects in gut epithelial maturation are also present as observed by immature morphology and a complete loss of alkaline phosphatase expression. Loss or gain of miR-145 function phenocopies defects observed with altered gata6 expression and accordingly, we show that miR-145 directly represses gata6, and that gata6 is a major miR-145 target in vitro and in vivo. miR-145 therefore plays a critical role in promoting the maturation of both layers of the gut during development through regulation of gata6.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.