ArticleBiophysical journal2009
Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.Molecules (Basel, Switzerland) · 2023Article
- BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.Nucleic acids research · 2020Article
- Conformation of G-quadruplex Controlled by Click Reaction.Molecules (Basel, Switzerland) · 2020Article
- A resonance Rayleigh scattering sensor for sensitive differentiation of telomere DNA length and monitoring special motifs (G-quadruplex and i-motif) based on the Ag nanoclusters and NAND logic gate responding to chemical input signals.Journal of nanobiotechnology · 2018Article
- Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.Biophysical journal · 2015Article
- Nucleic acid detection using G-quadruplex amplification methodologies.Methods (San Diego, Calif.) · 2013Review
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Authors and funding
6 authors.
Funding
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Abstract
Structural complexity is an inherent feature of the human telomeric sequence, and it presents a major challenge for developing ligands of pharmaceutical interest. Recent studies have pointed out that the induction of a quadruplex or change of a quadruplex conformation on binding may be the most powerful method to exert the desired biological effect. In this study, we demonstrate a quadruplex ligand that binds selectively to different forms of the human telomeric G-quadruplex structure and regulates its conformational switch. The results show that not only can oxazine750 selectively induce parallel quadruplex formation from a random coil telomeric oligonucleotide in the absence of added cations, it also can easily surpass the energy barrier between two structures and change the G-quadruplex conformation in Na(+) or K(+) solution. The combination of its unique properties, including the size and shape of the G-quadruplex and the small molecule, is proposed as the predominant force for regulating the special structural formation and transitions. These results may stimulate the design of new quadruplex binders that would be capable of discriminating different G-quadruplex structures as well as controlling biological phenomena, functional molecules, and nanomaterials.
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