ArticleBiophysical journal2009
Actin-myosin viscoelastic flow in the keratocyte lamellipod.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Computational insights on the interplay between electrotaxis and mechanotaxis.PLoS computational biology · 2026Article
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- Frictiotaxis underlies focal adhesion-independent durotaxis.Nature communications · 2025Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- Myosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin.Communications materials · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- The laminin-keratin link shields the nucleus from mechanical deformation and signalling.Nature materials · 2023Article
- The Influence of Nucleus Mechanics in Modelling Adhesion-independent Cell Migration in Structured and Confined Environments.Bulletin of mathematical biology · 2023Article
- Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022Review
- Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion.Molecular systems biology · 2021Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- Elastic wrinkling of keratocyte lamellipodia driven by myosin-induced contractile stress.Biophysical journal · 2021Article
- Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.Frontiers in cell and developmental biology · 2021Article
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.Biomechanics and modeling in mechanobiology · 2020Article
- Active random forces can drive differential cellular positioning and enhance motor-driven transport.Molecular biology of the cell · 2020Article
- A minimal mechanosensing model predicts keratocyte evolution on flexible substrates.Journal of the Royal Society, Interface · 2020Article
- Article
- Modeling the Shape of Synaptic Spines by Their Actin Dynamics.Frontiers in synaptic neuroscience · 2020Article
- Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
The lamellipod, the locomotory region of migratory cells, is shaped by the balance of protrusion and contraction. The latter is the result of myosin-generated centripetal flow of the viscoelastic actin network. Recently, quantitative flow data was obtained, yet there is no detailed theory explaining the flow in a realistic geometry. We introduce models of viscoelastic actin mechanics and myosin transport and solve the model equations numerically for the flat, fan-shaped lamellipodial domain of keratocytes. The solutions demonstrate that in the rapidly crawling cell, myosin concentrates at the rear boundary and pulls the actin network inward, so the centripetal actin flow is very slow at the front, and faster at the rear and at the sides. The computed flow and respective traction forces compare well with the experimental data. We also calculate the graded protrusion at the cell boundary necessary to maintain the cell shape and make a number of other testable predictions. We discuss model implications for the cell shape, speed, and bi-stability.
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