ReviewExpert review of vaccines2009
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience.
Review in Expert review of vaccines, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Fluorinated carbohydrate-based vaccines.Chemical science · 2026Review
- Targeting Siglec-Sialylated MUC1 Immune Axis in Cancer.Cancers · 2024Review
- Epimerisation in Peptide Synthesis.Molecules (Basel, Switzerland) · 2023Review
- Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments.Chemical reviews · 2022Review
- Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants.Frontiers in immunology · 2022Article
- A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model.Oncotarget · 2017Article
- Recent Advances in Subunit Vaccine Carriers.Vaccines · 2016Review
- Synthesis and characterization of a novel chemically designed (Globo)3-DTPA-KLH antigen.Drug design, development and therapy · 2015Article
- Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.MedChemComm · 2014Article
- A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic.Journal of the American Chemical Society · 2013Article
- Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Tumor-Associated Glycans and Immune Surveillance.Vaccines · 2013Review
- Boosting immunity to small tumor-associated carbohydrates with bacteriophage qβ capsids.ACS chemical biology · 2013Article
- Solving the convergence problem in the synthesis of triantennary N-glycan relevant to prostate-specific membrane antigen (PSMA).Journal of the American Chemical Society · 2012Article
- Divergent behavior of glycosylated threonine and serine derivatives in solid phase peptide synthesis.Organic letters · 2012Article
- Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis.Journal of the American Chemical Society · 2012Article
- Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer.Oncoimmunology · 2012Article
- Cancer vaccines and carbohydrate epitopes.Vaccine · 2011Review
- Natural and Induced Humoral Responses to MUC1.Cancers · 2011Article
- Grand challenge commentary: Synthetic immunology to engineer human immunity.Nature chemical biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Malignantly transformed cells can express aberrant cell surface glycosylation patterns, which serve to distinguish them from normal cells. This phenotype provides an opportunity for the development of carbohydrate-based vaccines for cancer immunotherapy. Synthetic carbohydrate-based vaccines, properly introduced through vaccination of a subject with a suitable construct, should be recognized by the immune system. Antibodies induced against these carbohydrate antigens could then participate in the eradication of carbohydrate-displaying tumor cells. Advances in carbohydrate synthetic capabilities have allowed us to efficiently prepare a range of complex, synthetic anticancer vaccine candidates. We describe herein the progression of our longstanding carbohydrate-based anticancer vaccine program, which is now at the threshold of clinical evaluation in several contexts. Our carbohydrate-based anticancer vaccine program has evolved through a number of stages: monomeric vaccines, monomeric clustered vaccines, unimolecular multi-antigenic vaccines and dual-acting vaccines. This account will focus on our recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.