ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2009
Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Human XIST: Origin and Divergence of aNon-coding RNA · 2025Review
- Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024Review
- The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development.The Biochemical journal · 2023Article
- Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation.Epigenetics & chromatin · 2022Article
- Interplay Between GH-regulated, Sex-biased Liver Transcriptome and Hepatic Zonation Revealed by Single-Nucleus RNA Sequencing.Endocrinology · 2022Article
- Gene regulation in time and space during X-chromosome inactivation.Nature reviews. Molecular cell biology · 2022Review
- Delete and survive: strategies of programmed genetic material elimination in eukaryotes.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Renal X-inactivation in female individuals with X-linked Alport syndrome primarily determined by age.Frontiers in medicine · 2022Article
- Programmed DNA Elimination in Vertebrates.Annual review of animal biosciences · 2021Review
- Dosage Compensation and Gene Expression of the X Chromosome in Sheep.G3 (Bethesda, Md.) · 2019Article
- Compensation of Dosage-Sensitive Genes on the Chicken Z Chromosome.Genome biology and evolution · 2016Article
- X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells.Stem cell reviews and reports · 2015Review
- The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?Cellular and molecular life sciences : CMLS · 2014Review
- Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.Genome biology and evolution · 2014Article
- Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.Genome research · 2014Article
- The evolutionary pathway of x chromosome inactivation in mammals.Acta naturae · 2013Article
- Sex-differential selection and the evolution of X inactivation strategies.PLoS genetics · 2013Article
- Article
- Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.Chromosoma · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the evolutionary origin of X inactivation mechanisms in mammals requires knowledge of features of X inactivation across all three major mammal lineages; monotremes, marsupials and eutherians. In the past, research into X inactivation in marsupials and monotremes lagged far behind the major advances made in understanding the mechanisms of X inactivation in human and mouse. Fragmentary knowledge of the genic content and sequence of marsupial and monotreme X chromosomes has been alleviated by the recent release of genome sequences for two marsupials and one monotreme. This has lead to a number of important findings, among which is the absence of XIST in marsupials and monotremes, and the surprising finding that X-borne genes in platypus are subject to stochastic transcriptional inhibition rather than whole chromosome inactivation. Availability of sequence data, and new techniques for studying expression and chromatin modification, now make rapid advance possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.