ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2009
Lessons from comparative analysis of X-chromosome inactivation in mammals.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024Review
- Dissecting the genomic regions of selection on the X chromosome in different cattle breeds.3 Biotech · 2024Article
- Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability.Genome biology · 2022Article
- DNA methylation and functional characterization of the XIST gene duringEpigenetics · 2019Article
- Allele-Specific Expression Analysis Does Not Support Sex Chromosome Inactivation on the Chicken Z Chromosome.Genome biology and evolution · 2017Article
- Embryonic loss of human females with partial trisomy 19 identifies region critical for the single active X.PloS one · 2017Article
- DNA methylation in hematopoietic development and disease.Experimental hematology · 2016Review
- Article
- Chromosome imbalance as a driver of sex disparity in disease.Journal of genomics · 2014Review
- Genomic insights into cancer-associated aberrant CpG island hypermethylation.Briefings in functional genomics · 2013Review
- Identification of the porcine XIST gene and its differential CpG methylation status in male and female pig cells.PloS one · 2013Article
- Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.Genome biology · 2012Article
- The STAT3-DNMT1 connection.JAK-STAT · 2012Article
- Review
- RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.Human genetics · 2011Article
- Evolutionary diversity and developmental regulation of X-chromosome inactivation.Human genetics · 2011Review
- Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.Reproduction (Cambridge, England) · 2011Review
- The single active X in human cells: evolutionary tinkering personified.Human genetics · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most mammals, X-chromosome inactivation is used as the strategy to achieve dosage compensation between XX females and XY males. This process is developmentally regulated, resulting in the differential treatment of the two X chromosomes in the same nucleus and mitotic heritability of the silent state. A lack of dosage compensation in an XX embryo is believed to result in early lethality, at least in eutherians. Given its fundamental importance, X-chromosome inactivation would be predicted to be a highly conserved process in mammals. However, recent studies have revealed major mechanistic differences in X inactivation between eutherians and marsupials, suggesting that the evolution of the X chromosome as well as developmental differences between mammals have led to diverse evolutionary strategies for dosage compensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.