ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2009
The worm solution: a chromosome-full of condensin helps gene expression go down.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Condensin I protects meiotic cohesin from WAPL-1 mediated removal.PLoS genetics · 2018Article
- Condensins promote chromosome individualization and segregation during mitosis, meiosis, and amitosis inMolecular biology of the cell · 2018Article
- Article
- Linking dosage compensation and X chromosome nuclear organization in C. elegans.Nucleus (Austin, Tex.) · 2015Article
- The onset of C. elegans dosage compensation is linked to the loss of developmental plasticity.Developmental biology · 2014Article
- Condensin-mediated chromosome organization and gene regulation.Frontiers in genetics · 2014Review
- The C. elegans dosage compensation complex mediates interphase X chromosome compaction.Epigenetics & chromatin · 2014Article
- DNA repair and genome maintenance in Bacillus subtilis.Microbiology and molecular biology reviews : MMBR · 2012Review
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
- Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.Molecular and cellular biology · 2012Article
- Contrasting roles of condensin I and condensin II in mitotic chromosome formation.Journal of cell science · 2012Article
- Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.Genetics research international · 2012Article
- Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dosage compensation in the nematode Caenorhabditis elegans is achieved by the binding of a condensin-like dosage compensation complex (DCC) to both X chromosomes in hermaphrodites to downregulate gene expression two-fold. Condensin I(DC), a sub-part of the DCC, differs from the mitotic condensin I complex by a single subunit, strengthening the connection between dosage compensation and mitotic chromosome condensation. The DCC is targeted to X chromosomes by initial binding to a number of recruiting elements, followed by dispersal or spreading to secondary sites. While the complex is greatly enriched on the X chromosomes, many sites on autosomes also bind the complex. DCC binding does not correlate with DCC-mediated repression, suggesting that the complex acts in a chromosome-wide manner, rather than on a gene-by-gene basis. Worm dosage compensation represents an excellent model system to study how condensin-mediated changes in higher order chromatin organization affect gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.