ReviewSeminars in immunopathology2009
Modeling multiple sclerosis in laboratory animals.
Review in Seminars in immunopathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Prognostic biomarkers of biliary atresia-are we there yet?Pediatric research · 2025Article
- PBMC-Humanized Mouse Model for Multiple Sclerosis: Studying Immune Changes and CNS Involvement.Bio-protocol · 2025Article
- MOGJournal of neuroinflammation · 2025Review
- Article
- The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation.Current topics in behavioral neurosciences · 2022Article
- In-Depth Characterization of Somatic and Orofacial Sensitive Dysfunctions and Interfering-Symptoms in a Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mouse Model.Frontiers in neurology · 2021Article
- TNFα in MS and Its Animal Models: Implications for Chronic Pain in the Disease.Frontiers in neurology · 2021Review
- Skipping adolescence to become super-inflammatory monocytes.Nature immunology · 2020Article
- Mitochondrial Dysfunction and Multiple Sclerosis.Biology · 2019Review
- Autophagy and Autophagy-Related Proteins in CNS Autoimmunity.Frontiers in immunology · 2017Review
- Sall1 is a transcriptional regulator defining microglia identity and function.Nature immunology · 2016Article
- Bioenergetics of the spinal cord in experimental autoimmune encephalitis of rats.BMC neuroscience · 2015Article
- Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation.Frontiers in immunology · 2015Review
- Optic Neuritis: A Model for the Immuno-pathogenesis of Central Nervous System Inflammatory Demyelinating Diseases.Current immunology reviews · 2015Article
- 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways.The Journal of pharmacology and experimental therapeutics · 2014Article
- Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models.Inflammopharmacology · 2014Review
- Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells.Journal of autoimmunity · 2013Article
- Effects of vaccination with altered Peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.Frontiers in neurology · 2013Article
- Neuropathic pain in animal models of nervous system autoimmune diseases.Mediators of inflammation · 2013Article
- End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology.Immunologic research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory demyelinating disease of the central nervous system is one of the most frequent causes of neurological disability in young adults. While in situ analysis and in vitro models do shed some light onto the processes of tissue damage and cellular interactions, the development of neuroinflammation and demyelination is a far too complex process to be adequately modeled by simple test tube systems. Thus, animal models using primarily genetically modified mice have been proven to be of paramount importance. In this chapter, we discuss recent advances in modeling brain diseases focusing on murine models and report on new tools to study the pathogenesis of complex diseases such as multiple sclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.