ArticleDrug discovery today. Disease models2008
Drosophila melanogaster as a model system for genetics of postnatal cardiac function.
Article in Drug discovery today. Disease models, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Animal models in biomedical research: Relevance ofHeliyon · 2025Review
- Current genetic models for studying congenital heart diseases: Advantages and disadvantages.Bioinformation · 2024Article
- The opportunities and challenges of usingFrontiers in physiology · 2023Article
- Public perception of laboratory animal testing: Historical, philosophical, and ethical view.Addiction biology · 2021Review
- Model system identification of novel congenital heart disease gene candidates: focus on RPL13.Human molecular genetics · 2019Article
- Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases.Annual review of nutrition · 2019Review
- Article
- A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.Journal of molecular biology · 2016Article
- Modeling congenital disease and inborn errors of development in Drosophila melanogaster.Disease models & mechanisms · 2016Review
- Cardiac responses to hypoxia and reoxygenation in Drosophila.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping.The Journal of clinical investigation · 2015Article
- Alternatives to animal testing: A review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Review
- Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.Molecular metabolism · 2014Article
- A Drosophila model of high sugar diet-induced cardiomyopathy.PLoS genetics · 2013Article
- Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.PLoS genetics · 2013Article
- Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction.Journal of cellular and molecular medicine · 2012Review
- Clinical considerations of heritable factors in common heart failure.Circulation. Cardiovascular genetics · 2011Review
- Drosophila, genetic screens, and cardiac function.Circulation research · 2011Review
- Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.Pharmacological reviews · 2011Review
- A method to measure myocardial calcium handling in adult Drosophila.Circulation research · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The fruit fly, Drosophila melanogaster, is an excellent model system that has a vast set of molecular tools and mutants to dissect the genetic pathways that are responsible for the normal and abnormal cardiac function. While the majority of studies have focused on heart development in the Drosophila embryo, attention has recently focused on the structure and function of the adult fly heart as a model of human heart failure. Here we review strategies to identify novel genes and pathways that cause or modify dilated cardiomyopathy in adult Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.