ArticleInternational journal of mass spectrometry2008
EVALUATION OF THE EXPERIMENTAL PARAMETERS WHICH CONTROL ELECTRON DETACHMENT DISSOCIATION, AND THEIR EFFECT ON THE FRAGMENTATION EFFICIENCY OF GLYCOSAMINOGLYCAN CARBOHYDRATES.
Article in International journal of mass spectrometry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Developments in Mass Spectrometry for Glycosaminoglycan Analysis: A Review.Molecular & cellular proteomics : MCP · 2021Review
- Structural Characterization of Sulfated Glycosaminoglycans Using Charge-Transfer Dissociation.Journal of the American Society for Mass Spectrometry · 2020Article
- A Scoring Algorithm for the Automated Analysis of Glycosaminoglycan MS/MS Data.Journal of the American Society for Mass Spectrometry · 2019Article
- Structural Characterization of Glycosaminoglycan Carbohydrates Using Ultraviolet Photodissociation.Analytical chemistry · 2019Article
- An Automated, High-Throughput Method for Interpreting the Tandem Mass Spectra of Glycosaminoglycans.Journal of the American Society for Mass Spectrometry · 2018Article
- Negative Electron Transfer Dissociation Sequencing of Increasingly Sulfated Glycosaminoglycan Oligosaccharides on an Orbitrap Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2017Article
- Glycosaminoglycan Analysis by Cryogenic Messenger-Tagging IR Spectroscopy Combined with IMS-MS.Analytical chemistry · 2017Article
- High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans.Journal of the American Society for Mass Spectrometry · 2014Article
- Oligosaccharide analysis by mass spectrometry: a review of recent developments.Analytical chemistry · 2014Review
- De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation.Analytical chemistry · 2013Article
- Detailed glycan structural characterization by electronic excitation dissociation.Analytical chemistry · 2013Article
- Structurally informative tandem mass spectrometry of highly sulfated natural and chemoenzymatically synthesized heparin and heparan sulfate glycosaminoglycans.Molecular & cellular proteomics : MCP · 2013Article
- Characterization of modified RNA by top-down mass spectrometry.Angewandte Chemie (International ed. in English) · 2012Article
- Multistage Tandem Mass Spectrometry of Chondroitin Sulfate and Dermatan Sulfate.International journal of mass spectrometry · 2011Article
- Electron detachment dissociation for top-down mass spectrometry of acidic proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Multivariate analysis of electron detachment dissociation and infrared multiphoton dissociation mass spectra of heparan sulfate tetrasaccharides differing only in hexuronic acid stereochemistry.Journal of the American Society for Mass Spectrometry · 2011Article
- Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates.European journal of mass spectrometry (Chichester, England) · 2011Article
- Top-down mass spectrometry for sequencing of larger (up to 61 nt) RNA by CAD and EDD.Journal of the American Society for Mass Spectrometry · 2010Article
- Glycosaminoglycan characterization by electrospray ionization mass spectrometry including fourier transform mass spectrometry.Methods in enzymology · 2010Article
- Electron-induced dissociation of glycosaminoglycan tetrasaccharides.Journal of the American Society for Mass Spectrometry · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The efficiency of conversion of precursor ions to observable products for electron detachment dissociation (EDD) was measured as a function of the key experimental parameters to determine their optimal values for the Fourier transform mass spectrometry analysis of anionic glycosaminoglycan carbohydrates. These parameters include electron current, electron energy, dispenser cathode heater current, electron beam duration, charge state of the precursor ion, oligomer length, and precursor ion number accumulated in an external radio frequency multipole trap. Precursor conversion is most efficient at an electron current of 15 µA, and decreases at higher and lower values. The conversion of precursor to product ions increases in efficiency as the electron pulse duration is increased. Together, these data suggest that a radially repulsive electric field is produced between the electron beam and negative ions during EDD which causes the reaction cross section to decrease at higher values of electron current (>15 µA). Elevating the heater current of the dispenser cathode increases the electron flux, but also causes ion activation, presumably by blackbody infrared irradiation. An electronic circuit is described that allows the electron current produced by the dispenser cathode to be measured during an EDD or electron capture dissociation (ECD) experiment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.