ReviewBone marrow transplantation2009
Future of cord blood for non-oncology uses.
Review in Bone marrow transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity.Frontiers in cell and developmental biology · 2020Article
- Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells.Stem cell research & therapy · 2019Article
- DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells.Stem cells translational medicine · 2015Article
- Impact of umbilical cord blood-derived mesenchymal stem cells on cardiovascular research.BioMed research international · 2015Review
- Human cord blood mononuclear cell transplantation for the treatment of premature ovarian failure in nude mice.International journal of clinical and experimental medicine · 2015Article
- Hematopoietic stem cells in neonates: any differences between very preterm and term neonates?PloS one · 2014Article
- Umbilical cord blood banking: from personal donation to international public registries to global bioeconomy.Journal of blood medicine · 2014Review
- Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.Cardiovascular & hematological disorders drug targets · 2014Review
- Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice.PloS one · 2013Article
- Viability and neural differentiation of mesenchymal stem cells derived from the umbilical cord following perinatal asphyxia.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- A comparative analysis of the opinions from European national and international ethics committees regarding the collection, storage and use of umbilical cord blood.Blood transfusion = Trasfusione del sangue · 2012Review
- Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.Stem cell research & therapy · 2011Article
- Re: Stem cells derived from cord blood in transplantation and regenerative medicine. Further phenomena.Deutsches Arzteblatt international · 2010Article
- Stem cells derived from cord blood in transplantation and regenerative medicine.Deutsches Arzteblatt international · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the last 5 years cord blood (CB) has been under intense experimental investigation in in vitro differentiation models and in preclinical animal models ranging from bone to muscle regeneration, cardiovascular diseases including myocardial and peripheral arterial disease, stroke and Parkinson's disease. On the basis of its biological advantages, CB can be an ideal source for tissue regeneration. However, in the hype of the so-called 'plasticity', many cell types have been characterized either on cell surface Ag expression alone or by RNA expression only, and without detailed characterization of genetic pathways; frequently, cells are defined without analysis of cellular function in vitro and in vivo, and the definition of the lineage of origin and cells have not been defined in preclinical studies. Here, we explore not only the most consistent data with regard to differentiation of CB cells in vitro and in vivo, but also show technical limitations, such as why in contrast to cell populations isolated from fresh CB, cryopreserved CB is not the ideal source for tissue regeneration. By taking advantage of numerous CB units discarded due to lack of sufficient hematopoietic cells for clinical transplantation, new concepts to produce off-the-shelf products are presented as well.
Indexed as
Identifiers
19802027What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.