ArticleGenome research2009
Rapid inexpensive genome-wide association using pooled whole blood.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.BMC genomics · 2023Pooled it
- High-throughput sequencing of pooled samples to determine community-level microbiome diversity.Annals of epidemiology · 2019Trial
- The illusion of polygenicity in pool-seq genetic mapping studies: insufficient power can mask simple genetic architectures.Genetics · 2026Article
- Article
- Review
- Pooled DNA sequencing in hairy vetch (Frontiers in plant science · 2024Article
- Article
- Exploiting genomic synteny in Felidae: cross-species genome alignments and SNV discovery can aid conservation management.BMC genomics · 2021Article
- Evaluating Accuracy of DNA Pool Construction Based on White Blood Cell Counts.Frontiers in genetics · 2021Article
- Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach.International journal of obesity (2005) · 2018Article
- A genome-wide association study of essential hypertension in an Australian population using a DNA pooling approach.Molecular genetics and genomics : MGG · 2017Article
- Estimating the genetic merit of sires by using pooled DNA from progeny of undetermined pedigree.Genetics, selection, evolution : GSE · 2017Article
- Pooled genome wide association detects association upstream of FCRL3 with Graves' disease.BMC genomics · 2016Article
- Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration.Scientific reports · 2016Article
- Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study.BioMed research international · 2015Article
- Quantitative analysis of low-density SNP data for parentage assignment and estimation of family contributions to pooled samples.Genetics, selection, evolution : GSE · 2014Article
- Article
- Genome-wide association study for ovarian cancer susceptibility using pooled DNA.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
- Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of featherless chickens.BMC genomics · 2012Article
- APJ1 and GRE3 homologs work in concert to allow growth in xylose in a natural Saccharomyces sensu stricto hybrid yeast.Genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWAS) have now successfully identified important genetic variants associated with many human traits and diseases. The high cost of genotyping arrays in large data sets remains the major barrier to wider utilization of GWAS. We have developed a novel method in which whole blood from cases and controls, respectively, is pooled prior to DNA extraction for genotyping. We demonstrate proof of principle by clearly identifying the associated variants for eye color, age-related macular degeneration, and pseudoexfoliation syndrome in cohorts not previously studied. Blood pooling has the potential to reduce GWAS cost by several orders of magnitude and dramatically shorten gene discovery time. This method has profound implications for translation of modern genetic approaches to a multitude of diseases and traits yet to be analyzed by GWAS, and will enable developing nations to participate in GWAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.