ArticleThe Journal of biological chemistry2009
Generation of long RNA chains in water.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Clay Minerals, Panacea or Parameter in RNA Oligomerization?Journal of molecular evolution · 2026Article
- The secret life of RNA and lipids.RNA biology · 2025Review
- High-Yield Prebiotic Polymerization of 2',3'-Cyclic Nucleotides under Wet-Dry Cycling.ACS central science · 2025Article
- The "Bagno dell'Acqua" Lake as a Novel Mars-like Analogue: Prebiotic Syntheses of PNA and RNA Building Blocks and Oligomers.International journal of molecular sciences · 2025Article
- Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.iScience · 2023Article
- Mineral-Mediated Oligoribonucleotide Condensation: Broadening the Scope of Prebiotic Possibilities on the Early Earth.Life (Basel, Switzerland) · 2023Article
- Which came first: the chicken, the egg, or guanine?RNA (New York, N.Y.) · 2023Article
- Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses.Astrobiology · 2022Article
- Trinity of G-tetrads and origin of translation.Biology direct · 2022Article
- Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Quadruplex World.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3',5' Cyclic Nucleotide Precursors.Life (Basel, Switzerland) · 2021Review
- Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals.Life (Basel, Switzerland) · 2020Article
- Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides.RNA (New York, N.Y.) · 2020Article
- Emergence of life in an inflationary universe.Scientific reports · 2020Article
- A Polyaddition Model for the Prebiotic Polymerization of RNA and RNA-Like Polymers.Life (Basel, Switzerland) · 2020Article
- Non-Enzymatic Assembly of a Minimized RNA Polymerase Ribozyme.ChemSystemsChem · 2019Article
- Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA.Life (Basel, Switzerland) · 2018Review
- Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Rewarming the Primordial Soup: Revisitations and Rediscoveries in Prebiotic Chemistry.Chembiochem : a European journal of chemical biology · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of RNA chains from 3',5'-cAMP and 3',5'-cGMP was observed. The RNA chains formed in water, at moderate temperatures (40-90 degrees C), in the absence of enzymes or inorganic catalysts. As determined by RNase analyses, the bonds formed were canonical 3',5'-phosphodiester bonds. The polymerizations are based on two reactions not previously described: 1) oligomerization of 3', 5'-cGMP to approximately 25-nucleotide-long RNA molecules, and of 3',5'-cAMP to 4- to 8-nucleotide-long molecules. Oligonucleotide A molecules were further extended by reciprocal terminal ligation to yield RNA molecules up to >120 nucleotides long and 2) chain extension by terminal ligation of newly polymerized products of 3',5'-cGMP on preformed oligonucleotides. The enzyme- and template-independent synthesis of long oligomers in water from prebiotically affordable precursors approaches the concept of spontaneous generation of (pre)genetic information.
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