ArticleEukaryotic cell2009
Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Bradyzoite subtypes rule the crossroads of Toxoplasma development.Nature communications · 2026Article
- Intra-strain genetic heterogeneity in Toxoplasma gondii ME49: Oxford Nanopore long-read sequencing reveals copy number variation in the ROP8-ROP2A locus.BMC genomics · 2025Article
- The GPI sidechain ofmBio · 2024Article
- Effective factors in the pathogenesis ofHeliyon · 2024Review
- A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii.Scientific reports · 2023Article
- Unifying Virulence Evaluation inFrontiers in cellular and infection microbiology · 2022Review
- Article
- Toxoplasma Effectors that Affect Pregnancy Outcome.Trends in parasitology · 2021Review
- The zebrafish as a novel model for theDisease models & mechanisms · 2020Article
- Article
- Modeling the Ruminant Placenta-Pathogen Interactions in Apicomplexan Parasites: Current and Future Perspectives.Frontiers in veterinary science · 2020Review
- Influence of the Host and Parasite Strain on the Immune Response DuringFrontiers in cellular and infection microbiology · 2020Review
- Molecular Basis of The Retinal Pigment Epithelial Changes That Characterize The Ocular Lesion in Toxoplasmosis.Microorganisms · 2019Article
- Expression of Long Non-Coding RNAs by Human Retinal Müller Glial Cells Infected with Clonal and Exotic VirulentNon-coding RNA · 2019Article
- AmBio · 2019Article
- Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection WithFrontiers in immunology · 2019Article
- Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis.PLoS pathogens · 2018Article
- Selection of Reference Genes for Studies of Human Retinal Endothelial Cell Gene Expression by Reverse Transcription-Quantitative Real-Time Polymerase Chain Reaction.Gene reports · 2018Article
- Virulence in Mice of aFrontiers in cellular and infection microbiology · 2018Article
- Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Toxoplasma gondii has an unusual population structure consisting of three clonal lineages that predominate in North America and Europe. This simple pattern has encouraged the use of only a few laboratory isolates that are representative of each lineage. Principle among these is the type I RH strain, originally isolated from a child with encephalitis some 70 years ago. Comparison of different passages of the RH strain that have been propagated differently over the intervening time period revealed that the commonly used clonal line called RH-ERP was not representative of natural isolates of the type I lineage. Notably, RH-ERP formed much larger plaques than other type 1 strains, including a separate, earlier derived isolate of the RH strain. The RH-ERP variant also showed enhanced extracellular survival, faster growth, and decreased differentiation compared to the prototype type I strain GT1. Comparison of gene expression differences in the RH-ERP line revealed that several ABC transporters were upregulated, which may provide a growth advantage in vitro. These findings illustrate that dramatic phenotypic changes can arise in laboratory strains, emphasizing the need for comparison with recent clinical isolates.
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