ArticleJournal of bacteriology2009
Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Roles of the components of theFuture microbiology · 2024Review
- Distinct regions ofeLife · 2022Article
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- The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton.Molecular microbiology · 2018Article
- Analyzing the role of CagV, a VirB8 homolog of the type IV secretion system ofFEBS open bio · 2017Article
- Crystal structure of the type IV secretion system component CagX from Helicobacter pylori.Acta crystallographica. Section F, Structural biology communications · 2017Article
- Article
- Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4.The Journal of biological chemistry · 2015Article
- Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.Future microbiology · 2015Review
- Article
- Article
- Impact of cagPAI and T4SS on the inflammatory response of human neutrophils to Helicobacter pylori infection.PloS one · 2014Article
- Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology.Molecular microbiology · 2013Article
- Cag type IV secretion system: CagI independent bacterial surface localization of CagA.PloS one · 2013Article
- Regulation of Helicobacter pylori adherence by gene conversion.Molecular microbiology · 2012Article
- Assembly and mechanisms of bacterial type IV secretion machines.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL.PloS one · 2012Article
- Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential.PLoS pathogens · 2012Article
- Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.PLoS pathogens · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Helicobacter pylori strains harboring the cag pathogenicity island (PAI) have been associated with more severe gastric disease in infected humans. The cag PAI encodes a type IV secretion (T4S) system required for CagA translocation into host cells as well as induction of proinflammatory cytokines, such as interleukin-8 (IL-8). cag PAI genes sharing sequence similarity with T4S components from other bacteria are essential for Cag T4S function. Other cag PAI-encoded genes are also essential for Cag T4S, but lack of sequence-based or structural similarity with genes in existing databases has precluded a functional assignment for the encoded proteins. We have studied the role of one such protein, Cag3 (HP0522), in Cag T4S and determined Cag3 subcellular localization and protein interactions. Cag3 is membrane associated and copurifies with predicted inner and outer membrane Cag T4S components that are essential for Cag T4S as well as putative accessory factors. Coimmunoprecipitation and cross-linking experiments revealed specific interactions with HpVirB7 and CagM, suggesting Cag3 is a new component of the Cag T4S outer membrane subcomplex. Finally, lack of Cag3 lowers HpVirB7 steady-state levels, further indicating Cag3 makes a subcomplex with this protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.