ArticleMolecular immunology2009
The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Article
- The Primate Major Histocompatibility Complex: A Case Study of Gene Family Evolution.bioRxiv : the preprint server for biology · 2025Article
- TheFrontiers in immunology · 2023Article
- Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution.BMC evolutionary biology · 2020Article
- The HLA A03 Supertype and SeveralJournal of virology · 2020Article
- Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.Immunogenetics · 2019Article
- Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini).PloS one · 2014Article
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Evolution of HLA-DRB genes.Molecular biology and evolution · 2012Article
- Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species.Immunogenetics · 2012Article
- Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection.The Journal of experimental medicine · 2012Article
- Review and hypothesis: does Graves' disease develop in non-human great apes?Thyroid : official journal of the American Thyroid Association · 2011Review
- Genomic plasticity of the MHC class I A region in rhesus macaques: extensive haplotype diversity at the population level as revealed by microsatellites.Immunogenetics · 2011Article
- Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force.Immunogenetics · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In humans, great apes, and different monkey species, the major histocompatibility complex (MHC) class II DRB region is known to display considerable copy number variation. The microsatellite D6S2878 has been shown to be a valuable marker for haplotyping the DR region in humans and macaque species. The present report illustrates that chimpanzee haplotypes also can be discriminated with this marker. The analyses resulted in the description of nine different region configurations, of which seven are present within the West African chimpanzee population studied. The region configurations vary in gene content from two up to five DRB genes. Subsequent cDNA sequencing increased the number of known full-length Patr-DRB sequences from 3 to 32, and shows that one to three Patr-DRB genes per haplotype apparently produce functional transcripts. This is more or less comparable to humans and rhesus macaques. Moreover, microsatellite analysis in concert with full-length DRB gene sequencing showed that the Patr-DRB*W9 and -DRB3*01/02 lineages most likely arose from a common ancestral lineage: hence, the Patr-DRB*W9 lineage was renamed to Patr-DRB3*07. Overall, the data demonstrate that the D6S2878 microsatellite marker allows fast and accurate haplotyping of the Patr-DRB region. In addition, the limited amount of allelic variation observed at the various Patr-DRB genes is in agreement with the fact that chimpanzees experienced a selective sweep that may have been caused by an ancient retroviral infection.
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