ArticleThe Journal of allergy and clinical immunology2009
Novel relationship of serum cholesterol with asthma and wheeze in the United States.
Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Glycolytic-Cholesterol Subtypes of Severe Asthma Reveal Distinct Immune-Inflammatory and Metabolic Phenotypes.Journal of inflammation research · 2026Article
- Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough.Lipids in health and disease · 2025Article
- Association between monocyte-high-density lipoprotein cholesterol ratio and mortality in a population with asthma: a cohort study.Lipids in health and disease · 2025Article
- Impact of metabolic and weight components on incident asthma using a real-world cohort.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Gender-specific association between a lipid composite index and asthma among US adults: insights from a population-based study.Lipids in health and disease · 2024Article
- Article
- Prevalence of Metabolic Abnormalities and their Association with Asthma Symptom Control in Children.Indian journal of pediatrics · 2024Article
- Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model.Clinical and experimental pediatrics · 2023Article
- Sterols and immune mechanisms in asthma.The Journal of allergy and clinical immunology · 2023Review
- Multiancestral polygenic risk score for pediatric asthma.The Journal of allergy and clinical immunology · 2022Article
- The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System.International journal of molecular sciences · 2022Review
- The relationship between high-density lipoprotein cholesterol and overall sleep quality in the adult population with asthma.Sleep and biological rhythms · 2022Article
- Subtyping children with asthma by clustering analysis of mRNA expression data.Frontiers in genetics · 2022Article
- Association Between Atopic Dermatitis, Asthma, and Serum Lipids: A UK Biobank Based Observational Study and Mendelian Randomization Analysis.Frontiers in medicine · 2022Article
- What's the deal with efferocytosis and asthma?Trends in immunology · 2021Review
- Additive Effect of Obesity and Dyslipidemia on Wheezing in Korean Adults: A Nationwide Representative Survey Study.Allergy, asthma & immunology research · 2021Article
- Lipid Nutrition in Asthma.Cell biochemistry and biophysics · 2021Review
- Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma.American journal of respiratory cell and molecular biology · 2021Article
- High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions.Biomedicines · 2020Review
- Asthma and Obesity in Children.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundCholesterol exerts complex effects on inflammation. There has been little investigation of whether serum cholesterol is associated with asthma, an inflammatory airways disease with great public health impact.
objectiveTo determine relationships between levels of 3 serum cholesterol measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], and non-HDL-C) and asthma/wheeze in a sample representative of the US population.
methodsCross-sectional study of 7005 participants age >or=6 years from the 2005 to 2006 National Health and Nutrition Examination Survey.
resultsSerum TC and non-HDL-C were lower in patients with current asthma than in subjects without current asthma in the overall population (TC, 188.5 vs 192.2 mg/dL; non-HDL-C, 133.9 vs 137.7 mg/dL; P < .05 for both), whereas HDL-C was not different. Adjusted odds ratios (ORs) from multivariate logistic regression per 1-SD increase of TC and non-HDL-C for current asthma were 0.92 (95% CI, 0.86-0.98) and 0.91 (95% CI, 0.85-0.98), respectively. On racial/ethnic stratification, these relationships reflect marked reductions unique to Mexican Americans (MAs; TC, 171.4 vs 189.3 mg/dL; P < .001; OR, 0.62; 95% CI, 0.48-0.80; non-HDL-C, 119.8 vs 137.9 mg/dL; P < .001; OR, 0.62; 95% CI, 0.48-0.79). Among MAs, the adjusted OR for wheeze requiring medical attention was 0.57 (95% CI, 0.43-0.75) for TC and 0.53 (95% CI, 0.33-0.85) for non-HDL-C. Relationships between cholesterol and asthma/wheeze were independent of body mass index and serum C-reactive protein, and similar between atopic and nonatopic participants.
conclusionSerum TC and non-HDL-C are inversely related to asthma in the US population, chiefly reflecting a relationship among MAs.
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