ArticleAmerican journal of obstetrics and gynecology2009
Betamethasone dose and formulation for induced lung maturation in fetal sheep.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Glucocorticoids in pregnancy: a master-switch for fetal maturation.Endocrine reviews · 2026Review
- Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation.Animals : an open access journal from MDPI · 2022Review
- Association between betamethasone levels and respiratory distress syndrome in preterm births: A prospective cohort study.Clinical and translational science · 2022Article
- Administration of Antenatal Corticosteroids: Current State of Knowledge.Geburtshilfe und Frauenheilkunde · 2022Article
- Is Umbilical Cord Blood Therapy an Effective Treatment for Early Lung Injury in Growth Restriction?Frontiers in endocrinology · 2020Article
- Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques.Scientific reports · 2019Article
- Efficacy and safety of antenatal steroids.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.American journal of obstetrics and gynecology · 2018Article
- Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep.Pediatric research · 2017Article
- Effect of betamethasone, surfactant, and positive end-expiratory pressures on lung aeration at birth in preterm rabbits.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Antenatal steroids: can we optimize the dose?Current opinion in obstetrics & gynecology · 2014Review
- Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values.European radiology · 2013Article
- Effects of antenatal corticosteroids on the hypothalamic-pituitary-adrenocortical axis of the fetus and newborn: experimental findings and clinical considerations.American journal of obstetrics and gynecology · 2012Review
- Controversy: antenatal steroids.Clinics in perinatology · 2011Review
- Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.American journal of obstetrics and gynecology · 2010Article
- Metabolic and hormonal effects of antenatal betamethasone after 35 weeks of gestation.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveWe hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically. STUDY
designEwes with singleton pregnancies were treated with single doses of 0.25-mg/kg or 0.5-mg/kg betamethasone acetate, 4 doses of 0.25-mg/kg betamethasone phosphate, a single dose of 0.5-mg/kg betamethasone acetate+0.25-mg/kg betamethasone phosphate, 2 doses of 0.25-mg/kg betamethasone acetate+0.25-mg betamethasone phosphate or vehicle beginning 48 hours before preterm delivery. Fetal lung maturation was evaluated.
resultsAll treatments induced lung maturation relative to vehicle controls. The relatively insoluble betamethasone acetate resulted in low maternal blood betamethasone and no detectable fetal blood betamethasone in 2 of 3 fetuses, but it induced fetal lung maturation comparable to the 2-dose betamethasone acetate+betamethasone phosphate or 4 doses of betamethasone phosphate.
conclusionA single maternal dose of betamethasone acetate effectively induces fetal lung maturation in sheep with minimal fetal exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.