ArticleProgress in neuro-psychopharmacology & biological psychiatry2010
Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Two current biomarkers in major depressive disorder: peripapillary and subfoveal choroidal vascular indexes.International ophthalmology · 2026Article
- Evaluation of Antidepressant Activity of Capsaicin Nanoemulsion in Nicotine Withdrawal-Induced Depression in Mice.Brain sciences · 2023Article
- From microRNA to protein, linking the neurotrophic hypothesis of depression to the Wistar Kyoto rat.Neuroscience applied · 2023Article
- Behavioral effects of adult male mice induced by low-level acetamiprid, imidacloprid, and nicotine exposure in early-life.Frontiers in neuroscience · 2023Article
- Development of a Novel Retina-Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View.Frontiers in psychiatry · 2022Article
- Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity.Scientific reports · 2021Article
- The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.Drug and alcohol dependence · 2021Article
- Neurotoxicity of e-cigarettes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Review
- The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression.Frontiers in psychiatry · 2020Article
- Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats.Journal of psychiatric research · 2020Article
- Encapsulation of Mesenchymal Stem Cells: Dissecting the Underlying Mechanism of Mesenchymal Stem Cell Transplantation Therapy.Neuroscience insights · 2020Article
- Antidepressant effects of moxidectin, an antiparasitic drug, in a rat model of depression.Behavioural brain research · 2019Article
- Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior.Clinical pharmacology and translational medicine · 2019Article
- Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects.Molecular psychiatry · 2018Article
- Genetic Model to Study the Co-Morbid Phenotypes of Increased Alcohol Intake and Prior Stress-Induced Enhanced Fear Memory.Frontiers in genetics · 2018Article
- Instrumental conditioning for food reinforcement in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder.BMC research notes · 2017Article
- Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with Major Depressive Disorder.Noro psikiyatri arsivi · 2017Article
- Nicotinic Receptor Intervention in Parkinson's Disease: Future Directions.Clinical pharmacology and translational medicine · 2017Article
- Duality of Antidepressants and Neuroprotectants.Neurotoxicity research · 2016Review
- Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective.Frontiers in psychiatry · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The observed high incidence of smoking amongst depressed individuals has led to the hypothesis of 'self medication" with nicotine in some of these patients. The inbred Wistar-Kyoto (WKY) rats exhibit depressive-like characteristics as evidenced by exaggerated immobility in the forced swim test (FST). One aim of this study was to investigate whether nicotine may have an antidepressant-like effect in these animals. Moreover, because of human postmortem studies indicating a reduction of the hippocampus volume in depressed patients, it was of interest to determine whether such an anatomical anomaly may also be manifested in WKY rats and whether it would be affected by chronic nicotine treatment. Adult female WKY and their control Wistar rats were administered nicotine consecutively (0.2 mg/kg, i.p., once or twice daily for 14 days) and their activity in an open field, as well as their immobility in FST were assessed either 15 min or 18 h after the last injection. Another set of animals was treated twice daily with 0.2 mg/kg nicotine for 14 days and sacrificed on day 15 for stereological evaluation of the hippocampal volume. When tested 15 min after the last injection, once or twice daily nicotine exacerbated the immobility in the FST in WKY rats only. When tested 18 h after the last injection, only twice daily nicotine treatment resulted in less immobility in the FST in WKY rats. Open field locomotor activity was not affected by any nicotine regimen. WKY rats had significantly less hippocampal volume (approximately 20%) than Wistar rats which was not altered by nicotine. These findings further validate the use of WKY rats as an animal model of human depression and signify the importance of inherent genetic differences in final behavioral outcome of nicotine.
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