ArticlePhysiology & behavior2009
Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapse.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women.Pharmacology, biochemistry, and behavior · 2018Trial
- Impact of acute guanfacine administration on stress and cue reactivity in cocaine-dependent individuals.The American journal of drug and alcohol abuse · 2015Trial
- Yohimbine administration and cue-reactivity in cocaine-dependent individuals.Psychopharmacology · 2014Trial
- Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats.Addiction neuroscience · 2025Article
- Article
- Sex differences in cocaine self-administration by Wistar rats after predator odor exposure.Advances in drug and alcohol research · 2023Article
- Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking.Journal of neurochemistry · 2021Review
- Neural Substrates and Circuits of Drug Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders.Frontiers in behavioral neuroscience · 2020Review
- What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders.Neurobiology of stress · 2018Review
- Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.Biological psychiatry · 2018Article
- Exacerbated Craving in the Presence of Stress and Drug Cues in Drug-Dependent Patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Observational
- Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Adolescent-onset of cocaine use is associated with heightened stress-induced reinstatement of cocaine seeking.Addiction biology · 2016Article
- Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.Psychopharmacology · 2016Article
- Laboratory-induced stress and craving among individuals with prescription opioid dependence.Drug and alcohol dependence · 2015Article
- Multiple Properties of Drug-Paired Cues May Precipitate Reinstatement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues.Behavioral neuroscience · 2015Article
- Drug predictive cues activate aversion-sensitive striatal neurons that encode drug seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drug-associated cues and stress increase craving and lead to greater risk of relapse in abstinent drug addicts. This risk may be increased when these factors occur simultaneously. The current study examined whether the presentation of three different levels of intermittent footshock would trigger reinstatement or potentiate reinstatement of cocaine-seeking caused by conditioned cues. Male, Long Evans rats underwent daily i.v. cocaine self-administration, followed by extinction of lever responding in the absence of previously cocaine-paired cues. Reinstatement of cocaine-seeking was measured during presentation of cocaine-paired cues, following pretreatment with three levels of intermittent footshock (0.25, 0.5, and 0.75 mA), or after the combination of footshock and cues. Footshock at the 0.5 and 0.75 mA levels led to significant reinstatement when presented alone, and also potentiated the reinstatement triggered by the presentation of conditioned cues. These results demonstrate that while stress and drug-paired cues reinstate drug-seeking when presented in isolation, their interaction leads to potentiated reinstatement. Dual targeting of stress and cues is thus a critical consideration for treatment intervention in abstinent drug users.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.