ReviewFEBS letters2009
Spatially distributed cell signalling.
Review in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Cellular diffusion processes in singularly perturbed domains.Journal of mathematical biology · 2024Review
- NF-kB in Signaling Patterns and Its Temporal Dynamics Encode/Decode Human Diseases.Life (Basel, Switzerland) · 2022Review
- Can Systems Biology Advance Clinical Precision Oncology?Cancers · 2021Review
- A spatial model of YAP/TAZ signaling reveals how stiffness, dimensionality, and shape contribute to emergent outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- System, Method and Software for Calculation of a Cannabis Drug Efficiency Index for the Reduction of Inflammation.International journal of molecular sciences · 2020Article
- Proofreading through spatial gradients.eLife · 2020Article
- Cell shape regulates subcellular organelle location to control early CaScientific reports · 2020Article
- Article
- New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.Seminars in cancer biology · 2019Review
- Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks.Chemical reviews · 2018Review
- Relaxation oscillations and hierarchy of feedbacks in MAPK signaling.Scientific reports · 2017Article
- The Slow Mobility of the ParA Partitioning Protein Underlies Its Steady-State Patterning in Caulobacter.Biophysical journal · 2016Article
- Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia.PLoS computational biology · 2016Article
- Article
- Dynamics of gradient formation by intracellular shuttling.The Journal of chemical physics · 2015Article
- Computational modeling of drug response with applications to neuroscience.Dialogues in clinical neuroscience · 2014Review
- Dynamics and stability of a three-dimensional model of cell signal transduction.Journal of mathematical biology · 2013Article
- Complexity of receptor tyrosine kinase signal processing.Cold Spring Harbor perspectives in biology · 2013Review
- Dynamic optimization of distributed biological systems using robust and efficient numerical techniques.BMC systems biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Emerging evidence indicates that complex spatial gradients and (micro)domains of signalling activities arise from distinct cellular localization of opposing enzymes, such as a kinase and phosphatase, in signal transduction cascades. Often, an interacting, active form of a target protein has a lower diffusivity than an inactive form, and this leads to spatial gradients of the protein abundance in the cytoplasm. A spatially distributed signalling cascade can create step-like activation profiles, which decay at successive distances from the cell surface, assigning digital positional information to different regions in the cell. Feedback and feedforward network motifs control activity patterns, allowing signalling networks to serve as cellular devices for spatial computations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.