ArticleSchizophrenia research2009
The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.Molecular psychiatry · 2011Pooled it
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- Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis.Schizophrenia research · 2021Article
- Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.Schizophrenia research · 2016Review
- Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models.Neural plasticity · 2016Review
- Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus.Journal of neurodevelopmental disorders · 2016Article
- Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.Cell discovery · 2015Article
- Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia.Neurobiology of disease · 2013Review
- Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder.Psychiatric genetics · 2013Article
- Article
- Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.PloS one · 2011Article
- Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.Schizophrenia research · 2011Article
- Article
- Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Neuroscience and biobehavioral reviews · 2011Review
- Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.The Journal of biological chemistry · 2010Article
- Schizophrenia gene networks and pathways and their applications for novel candidate gene selection.PloS one · 2010Article
- No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
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Abstract
backgroundDTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples.
methodWe assessed nine single nucleotide polymorphisms (SNPs) in this gene for association with schizophrenia in a new sample of 1021 cases and 626 controls from Ireland.
resultsFour SNPs give evidence of association (0.000018<p<0.045), most strongly with the common allele at rs760761. A haplotype of the common alleles of five markers (including rs760761) and the minor allele of rs2619538 overlapping the 5' end of the DTNBP1 gene also gives evidence for association (p=0.0002). Secondary analyses showed no difference in the association signal based on sex or family history. These results are in agreement with the most consistently observed association with common alleles and common-allele haplotypes, reported in a previous study of Irish cases and controls but not in an Irish high-density family sample. Our results do not support the prior report from a Swedish sample of increased association in cases with a family history of psychotic illness. Comparison of human, chimpanzee and rhesus sequence suggest that rs760761 is a particularly variable position in the primate lineage.
conclusionThis study provides further evidence from a large case/control sample for association of common DTNBP1 alleles and haplotypes with schizophrenia.
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