ArticleJournal of affective disorders2010
Intermediate: cognitive phenotypes in bipolar disorder.
Article in Journal of affective disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital Phenotyping in Bipolar Disorder: Which Integration with Clinical Endophenotypes and Biomarkers?International journal of molecular sciences · 2020Pooled it
- Cognitive and neural abnormalities: working memory deficits in bipolar disorder offspring.Psychological medicine · 2025Article
- Relationships between cognition, functioning, and quality of life of euthymic patients with bipolar disorder: Structural equation modeling with the FACE-BD cohort.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics.iScience · 2024Article
- Limited time-specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders.Acta psychiatrica Scandinavica · 2022Article
- Cognitive subgroups and their longitudinal trajectories in bipolar disorder.Acta psychiatrica Scandinavica · 2022Article
- Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.Bipolar disorders · 2022Review
- C-reactive protein and affective inhibition in bipolar disorder.Journal of affective disorders · 2022Article
- The Effects of Bipolar Disorder Risk on a Mobile Phone Keystroke Dynamics Based Biomarker of Brain Age.Frontiers in psychiatry · 2021Article
- Metabolic Syndrome Impairs Executive Function in Bipolar Disorder.Frontiers in neuroscience · 2021Article
- Developing Dimensional, Pandiagnostic Inhibitory Control Constructs With Self-Report and Neuropsychological Data.Assessment · 2020Article
- Cognitive Control as a 5-HTFrontiers in psychology · 2019Article
- Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans.Nature communications · 2018Article
- Testing frameworks for personalizing bipolar disorder.Translational psychiatry · 2018Article
- Psychosis in bipolar disorder: Does it represent a more "severe" illness?Bipolar disorders · 2018Article
- Cohort Profile: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder.International journal of epidemiology · 2018Article
- Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI.Journal of affective disorders · 2018Article
- Equivalent linear change in cognition between individuals with bipolar disorder and healthy controls over 5 years.Bipolar disorders · 2017Article
- Domain-specific impairment in cognitive control among remitted youth with a history of major depression.Early intervention in psychiatry · 2017Article
- The gut microbiome composition associates with bipolar disorder and illness severity.Journal of psychiatric research · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundIntermediate cognitive phenotypes (ICPs) are measurable and quantifiable states that may be objectively assessed in a standardized method, and can be integrated into association studies, including genetic, biochemical, clinical, and imaging based correlates. The present study used neuropsychological measures as ICPs, with factor scores in executive functioning, attention, memory, fine motor function, and emotion processing, similar to prior work in schizophrenia.
methodsHealthy control subjects (HC, n=34) and euthymic (E, n=66), depressed (D, n=43), or hypomanic/mixed (HM, n=13) patients with bipolar disorder (BD) were assessed with neuropsychological tests. These were from eight domains consistent with previous literature; auditory memory, visual memory, processing speed with interference resolution, verbal fluency and processing speed, conceptual reasoning and set-shifting, inhibitory control, emotion processing, and fine motor dexterity.
resultsOf the eight factor scores, the HC group outperformed the E group in three (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity), the D group in seven (all except Inhibitory Control), and the HM group in four (Inhibitory Control, Processing Speed with Interference Resolution, Fine Motor Dexterity, and Auditory Memory). LIMITATIONS: The HM group was relatively small, thus effects of this phase of illness may have been underestimated. Effects of medication could not be fully controlled without a randomized, double-blind, placebo-controlled study.
conclusionsUse of the factor scores can assist in determining ICPs for BD and related disorders, and may provide more specific targets for development of new treatments. We highlight strong ICPs (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity) for further study, consistent with the existing literature.
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