ArticleMolecular immunology2009
Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.Cell reports · 2021Article
- Novel Interactions between the Human T-Cell Leukemia Virus Type 1 Antisense Protein HBZ and the SWI/SNF Chromatin Remodeling Family: Implications for Viral Life Cycle.Journal of virology · 2019Article
- Retracted Article: Structural characterization ofRSC advances · 2019Article
- Article
- LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.Angewandte Chemie (International ed. in English) · 2015Article
- LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2015Article
- Targeting bromodomains: epigenetic readers of lysine acetylation.Nature reviews. Drug discovery · 2014Review
- An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection.Journal of virology · 2013Article
- BET domain co-regulators in obesity, inflammation and cancer.Nature reviews. Cancer · 2012Review
- Bromodomains as therapeutic targets.Expert reviews in molecular medicine · 2011Review
- Emerging roles of the 26S proteasome in nuclear hormone receptor-regulated transcription.Biochimica et biophysica acta · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The induction of key pro-inflammatory genes is regulated by the SWI/SNF class of ATP-dependent remodeling complexes. In particular, the catalytic ATPase subunit, Brg1, is distinctly involved in the chromatin remodeling required for activating pro-inflammatory genes in a temporally, ordered fashion. Despite advances in our understanding of the role for Brg1 in the kinetics of inflammatory responses, little is known about the precise mechanisms which down-regulate Brg1 activity. Biochemical studies implicate a role for the proteasome in the regulation of SWI/SNF assembly and function; however, it is unclear if proteasome-dependent mechanisms modulate its remodeling activity or recruitment to chromatin in order to regulate inflammatory gene transcription. We now demonstrate for the first time that proteasome function represents an important mechanism for limiting inducible association of Brg1 with promoters of SWI/SNF-regulated, inflammatory genes. As a result, catalytic activity of the proteasome fine-tunes the kinetics of inflammatory gene transcription by inhibiting both premature and persistent chromatin remodeling at SWI/SNF-regulated genes. These results provide mechanistic insight into the interplay between nucleosome remodeling, inflammation and proteasome, and underscore the critical role of the proteasome in controlling both extent and duration of inflammatory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.