ArticleMolecular and cellular neurosciences2009
Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Investigating the shared genetic architecture between dry eye disease and multisite chronic pain.Frontiers in medicine · 2026Article
- The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025Review
- PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth.Journal of neuroendocrinology · 2024Article
- Identification of potential crucial genes and therapeutic targets for epilepsy.European journal of medical research · 2024Article
- Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.Scientific reports · 2016Article
- R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.Seminars in cell & developmental biology · 2015Review
- A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis.PloS one · 2015Article
- Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.Neurobiology of disease · 2015Article
- Substrate specificity of R3 receptor-like protein-tyrosine phosphatase subfamily toward receptor protein-tyrosine kinases.The Journal of biological chemistry · 2013Article
- Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.Cellular and molecular life sciences : CMLS · 2013Article
- Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack.The FEBS journal · 2013Review
- Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.Molecular and cellular biology · 2012Article
- Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.Molecular and cellular neurosciences · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The roles of protein tyrosine phosphatases (PTPs) in differentiation and axon targeting by dorsal root ganglion (DRG) neurons are essentially unknown. The type III transmembrane PTP, PTPRO, is expressed in DRG neurons, and is implicated in the guidance of motor and retinal axons. We examined the role of PTPRO in DRG development and function using PTPRO(-/-) mice. The number of peptidergic nociceptive neurons in the DRG of PTPRO(-/-) mice was significantly decreased, while the total number of sensory neurons appeared unchanged. In addition, spinal pathfinding by both peptidergic and proprioceptive neurons was abnormal in PTPRO(-/-) mice. Lastly, PTPRO(-/-) mice performed abnormally on tests of thermal pain and sensorimotor coordination, suggesting that both nociception and proprioception were perturbed. Our data indicate that PTPRO is required for peptidergic differentiation and process outgrowth of sensory neurons, as well as mature sensory function, and provide the first evidence that RPTPs regulate DRG development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.