ArticleMolecular and cellular endocrinology2010
IA-2 modulates dopamine secretion in PC12 cells.
Article in Molecular and cellular endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19).Molecular psychiatry · 2020Article
- A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.eLife · 2016Article
- Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2.Journal of translational medicine · 2016Article
- The Ia-2β intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice.Diabetologia · 2015Article
- The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.Neuroscience · 2014Article
- Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain.Diabetologia · 2013Article
- Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.American journal of physiology. Endocrinology and metabolism · 2012Article
- Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells.Journal of diabetes investigation · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The secretion of the hormone insulin from beta cells is modulated by the expression of the dense core vesicle transmembrane protein IA-2. Since IA-2 is found in neuroendocrine cells throughout the body, the present experiments were initiated to determine whether the expression of IA-2 also modulates the secretion of neurotransmitters. Using the dopamine-secreting pheochromocytoma cell line PC12, we found that the overexpressions of IA-2 increased the cellular content and secretion of dopamine, whereas the knockdown of IA-2 by siRNA decreased the cellular content and secretion of dopamine. Neither the overexpression nor knockdown of IA-2 influenced the uptake of [H(3)]dopamine by PC12 cells, but did influence the amount of [H(3)]dopamine secreted. Overexpression of IA-2 also increased the level of the dense core vesicle-associated proteins Rab3A, IA-2beta and secretogranin II, whereas the knockdown of IA-2 decreased the level of these proteins. We conclude that the expression of IA-2 profoundly influences the function of dense core vesicles and has a broad modulating effect on the cellular content and secretion of both hormones and neurotransmitters.
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