ArticleDigestive diseases and sciences2010
Expression of TIP30 tumor suppressor gene is down-regulated in human colorectal carcinoma.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress.Cancers · 2020Article
- Low TIP30 Protein Expression is Associated with a High Risk of Metastasis and Poor Prognosis for Non-Small-Cell Lung Cancer.Journal of clinical medicine · 2019Article
- Mechanism of membrane fusion: protein-protein interaction and beyond.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.Cancer science · 2018Article
- Reduction of Tat-interacting Protein 30 Expression Could be a Prognostic Marker in Bladder Urothelial Cancer.Chinese medical journal · 2018Article
- Association of TIP30 expression and prognosis of hepatocellular carcinoma in patients with HBV infection.Cancer medicine · 2016Article
- Overexpression of TIP30 inhibits the growth and invasion of glioma cells.Molecular medicine reports · 2016Article
- Article
- Long non-coding RNA growth arrest-specific transcript 5 in tumor biology.Oncology letters · 2015Article
- Decreased TIP30 promotes Snail-mediated epithelial-mesenchymal transition and tumor-initiating properties in hepatocellular carcinoma.Oncogene · 2015Article
- Clinicopathologic significance and survival of TIP30 expression in laryngeal squamous cell carcinoma.International journal of clinical and experimental medicine · 2015Article
- TIP30: A Novel Tumor-Suppressor Gene.Oncology research · 2014Review
- IL28B genotype and the expression of ISGs in normal liver.Liver international : official journal of the International Association for the Study of the Liver · 2013Article
- TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice.Oncogene · 2013Article
- CC3/TIP30 affects DNA damage repair.BMC cell biology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHuman TIP30 was initially identified as a candidate metastasis suppressor gene whose expression was down-regulated in human liver, lung, breast, and prostate cancers, and recently the role of this gene was examined in colorectal cancer. The aim of this study was to determine the level of TIP30 expression in colorectal carcinoma (CRC).
resultsTIP30 protein levels were lower in colorectal carcinomas compared to normal tissue from the control group (P < 0.001). The frequencies of hypermethylation of TIP30 in tumor were 36%, while there was no aberrant methylation in paired adjacent non-tumor tissue. A statistically significant inverse association was found between TIP30 methylation status and expression of the TIP30 protein in tumor tissues (P = 0.006). Somatic missense mutations in the TIP30 gene were identified in human CRC tissue specimens.
conclusionsOur results demonstrate that promoter methylation is involved in the decreased expression of TIP30 tumor suppressor gene in human colorectal carcinoma.
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