ReviewJournal of bioenergetics and biomembranes2009
Mitochondria and Alzheimer's disease: amyloid-beta peptide uptake and degradation by the presequence protease, hPreP.
Review in Journal of bioenergetics and biomembranes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases.Experimental neurobiology · 2023Review
- Orthologs of Human-Disease-Associated Genes in Plants Are Involved in Regulating Leaf Senescence.Life (Basel, Switzerland) · 2023Article
- Alzheimer's Disease: A Molecular View of β-Amyloid Induced Morbific Events.Biomedicines · 2021Review
- Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice.Current issues in molecular biology · 2021Article
- Article
- Some Molecular and Cellular Stress Mechanisms Associated with Neurodegenerative Diseases and Atherosclerosis.International journal of molecular sciences · 2021Review
- Molecular Targets in Alzheimer's Disease.Molecular neurobiology · 2019Review
- Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer's Disease Pathogenesis.Frontiers in aging neuroscience · 2019Review
- Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction.BioMed research international · 2018Article
- Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease.European journal of medicinal chemistry · 2014Article
- Mitochondrial dysfunction: different routes to Alzheimer's disease therapy.Oxidative medicine and cellular longevity · 2014Review
- Deconstructing mitochondrial dysfunction in Alzheimer disease.Oxidative medicine and cellular longevity · 2013Review
- In vitro oxidative inactivation of human presequence protease (hPreP).Free radical biology & medicine · 2012Article
- Amyloid-Beta interaction with mitochondria.International journal of Alzheimer's disease · 2011Article
- Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria.Journal of Alzheimer's disease : JAD · 2011Article
- Clinical aspects of melatonin intervention in Alzheimer's disease progression.Current neuropharmacology · 2010Article
- Amyloid-β as a modulator of synaptic plasticity.Journal of Alzheimer's disease : JAD · 2010Review
- Mitochondrial matters of the brain: amyloid formation and Alzheimer's disease introduction.Journal of bioenergetics and biomembranes · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence suggest mitochondrial dysfunction as a possible underlying mechanism of Alzheimer's disease (AD). Accumulation of the amyloid-beta peptide (Abeta), a neurotoxic peptide implicated in the pathogenesis of AD, has been detected in brain mitochondria of AD patients and AD transgenic mouse models. In vitro evidence suggests that the Abeta causes mitochondrial dysfunction e.g. oxidative stress, mitochondrial fragmentation and decreased activity of cytochrome c oxidase and TCA cycle enzymes. Here we review the link between mitochondrial dysfunctions and AD. In particular we focus on the mechanism for Abeta uptake by mitochondria and on the recently identified Abeta degrading protease in human brain mitochondria.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.