An updating meta-analysis of the glutathione S-transferase T1 polymorphisms and colorectal cancer risk: a HuGE review.

introductionGSTT1 status has been extensively studied as a colorectal cancer risk factor. However, the results are inconsistent. To examine this controversy, we performed a meta-analysis to evaluate the relationship between GSTT1 polymorphism and colorectal cancer. MATERIALS AND

methodsWe performed a literature search using PUBMED, EMBASE, Cochrane Library, and HuGNet database to February 2009, with no restrictions. All articles were independent and contained the minimum information necessary to estimate the colorectal cancer risk associated with GSTT1 null. Summary odds ratio (ORs) and 95% confidence intervals (CIs) were calculated using random-effect or fixed-effect models based on the heterogeneity of included studies.

resultsA total of 23 case-control studies, including a total of 11,057 subjects (5,058 cases and 5,999 controls), that related to GSTT1 polymorphism and risk of colorectal cancer were identified and included for analysis. The random-effect meta-analyses of all the 23 studies suggested that there was a small increased risk of colorectal cancer for individuals with GSTT1 null (OR was 1.23; 95% CI 1.02-1.49; I (2) = 76.9%, P for heterogeneity <0.001). The fixed-effect meta-analyses reached a similar results in Caucasians populations of ten studies (OR = 1.39; 95% CI 1.21-1.59; I (2) = 29.8%, P for heterogeneity = 0.171) and Asians populations of five studies (OR = 1.23; 95% CI 1.04-1.45; I (2) = 0.0%, P for heterogeneity = 0.428), with as inversely association in the other ethnic populations from four studies (OR = 0.69; 95% CI 0.54-0.877; I (2) = 0.0%, P for heterogeneity = 0.58).

conclusionThere was a small increased risk of colorectal cancer for individuals with GSTT1 null, especially for Caucasians populations and Asian populations.