ArticlePsychopharmacology2009
Social experiences affect reinstatement of cocaine-induced place preference in mice.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- Distinctive behavioral and neurochemical profile of social stress in male and female adolescent mice.Biology of sex differences · 2026Article
- Prelimbic cortex to ventral tegmental area projection regulates early social isolation stress-potentiated heroin seeking in mice.Nature communications · 2025Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Deletion ofFrontiers in pharmacology · 2023Article
- Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system.Psychopharmacology · 2022Article
- Article
- Distinct Regulation of Dopamine D3 Receptor in the Basolateral Amygdala and Dentate Gyrus during the Reinstatement of Cocaine CPP Induced by Drug Priming and Social Stress.International journal of molecular sciences · 2021Article
- Social interaction reward in rats has anti-stress effects.Addiction biology · 2021Article
- Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats.Frontiers in pharmacology · 2021Article
- Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.Psychopharmacology · 2021Article
- Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward.International journal of molecular sciences · 2020Article
- The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction.Frontiers in neural circuits · 2020Review
- Social Housing Conditions Modulate the Long-Lasting Increase in Cocaine Reward Induced by Intermittent Social Defeat.Frontiers in behavioral neuroscience · 2019Article
- Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF.Neurobiology of stress · 2018Review
- Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm.Journal of visualized experiments : JoVE · 2018Article
- Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism.Psychopharmacology · 2018Article
- Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.Psychopharmacology · 2017Article
- Stress, sex, and motivated behaviors.Journal of neuroscience research · 2017Review
- A Method for Psychosocial Stress-Induced Reinstatement of Cocaine Seeking in Rats.Biological psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleDrug addiction is a multifactorial disorder resulting from an interaction between genetic and environmental factors, and negative and positive environmental conditions may increase or reduce, respectively, vulnerability to drug addiction.
objectivesThe influence of different social experiences on the acquisition, extinction, and reinstatement of a cocaine-induced conditioned place preference (CPP) was evaluated.
methodsIn experiment 1, adolescent and adult male OF1 mice housed under four different conditions (grouped, isolated, crowded, and cohabitating with a female) were conditioned with 50, 12.5, or 3.125 mg/kg of cocaine. All mice underwent extinction sessions until the CPP was extinguished. The effects of cocaine priming injections on the reinstatement of CPP were then evaluated. In experiment 2, the effect of different social experiences on the maintenance and reinstatement of cocaine-CPP in adult mice was studied.
resultsAlthough housing conditions did not affect the acquisition of cocaine-CPP, it did modify reinstatement after extinction. Adolescent mice living in crowded conditions or cohabitating with a female did not present reinstatement after cocaine priming. Similarly, neither isolated adult mice nor adults cohabitating with a female presented reinstatement. In grouped adult mice, isolation after acquisition of the CPP and social defeat before reinstatement increased the vulnerability to reinstatement induced by cocaine priming. Conversely, both exposure to females and a brief social interaction undermined cocaine-induced reinstatement.
conclusionsSocial experiences modify vulnerability to reinstatement, acting as prevention or risk factors in the development of drug addiction.
Indexed as
Identifiers
19798482What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.