ReviewJournal of molecular medicine (Berlin, Germany)2010
T cell cross-talk with kidney dendritic cells in glomerulonephritis.
Review in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Resolving Inflammation in CKD: The Potential of SPMs and Omega-3 Derivatives as Biomarkers and Therapeutics.Biomedicines · 2026Review
- Liquid-liquid phase separation-related genes in the immune microenvironment and diagnosis of focal segmental glomerulosclerosis and minimal change disease.Renal failure · 2025Article
- Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia.Scientific reports · 2025Article
- Angiotensin II and post-streptococcal glomerulonephritis.Clinical and experimental nephrology · 2024Review
- Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway.Drug design, development and therapy · 2024Article
- Immune Dysfunction in Uremia 2020.Toxins · 2020Review
- Brain-kidney interaction: Renal dysfunction following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regulating CD4Stem cells international · 2020Article
- Danger control programs cause tissue injury and remodeling.International journal of molecular sciences · 2013Review
- A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells.Journal of translational medicine · 2013Article
- Immune and inflammatory role in renal disease.Comprehensive Physiology · 2013Review
- Immune dysfunction in uremia—an update.Toxins · 2012Review
- The renal mononuclear phagocytic system.Journal of the American Society of Nephrology : JASN · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells have long been suspected to contribute to glomerulonephritis not only as helpers for antibody-producing B cells, but also as immune effector cells. Recent evidence has substantiated this hypothesis, by identifying tubulointerstitial dendritic cells (DCs) as crucial interaction partners. Kidney DCs capture glomerular antigens released for example by cytotoxic CD8(+) T cells and present them to infiltrating CD4(+) T helper cells. This cross-talk results in the production of proinflammatory cytokines and chemokines that recruit and activate further immune effector cells. Such immunocytes are the main components of the well-known tubulointerstitial mononuclear infiltrate characteristic of progressive renal disease. These findings indicate that effector T cell dysregulation by intrarenal DCs and by the chemokines they produce represents a hitherto unknown mechanism by which glomerular damage can cause chronic tubulointerstitial inflammation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.