ArticlePLoS pathogens2009
Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.
Article in PLoS pathogens, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Cyclic strain of poly (methyl methacrylate) surfaces triggered the pathogenicity of Candida albicans.Acta biomaterialia · 2023Article
- Review
- Review
- Spectrum-Effect Relationships Between the Bioactive Ingredient ofFrontiers in pharmacology · 2018Article
- Essential Oils and Antifungal Activity.Pharmaceuticals (Basel, Switzerland) · 2017Review
- The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells.Journal of fungi (Basel, Switzerland) · 2017Review
- A Family of Secretory Proteins Is Associated with Different Morphotypes in Cryptococcus neoformans.Applied and environmental microbiology · 2017Article
- Candida albicans cell-type switching and functional plasticity in the mammalian host.Nature reviews. Microbiology · 2017Review
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Transcriptional control of sexual development in Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2016Review
- Comparison of Switching and Biofilm Formation between MTL-Homozygous Strains of Candida albicans and Candida dubliniensis.Eukaryotic cell · 2015Article
- Role of Tec1 in the development, architecture, and integrity of sexual biofilms of Candida albicans.Eukaryotic cell · 2015Article
- Candida albicans Biofilms and Human Disease.Annual review of microbiology · 2015Review
- White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.PLoS genetics · 2014Article
- Sexual biofilm formation in Candida tropicalis opaque cells.Molecular microbiology · 2014Article
- Unisexual reproduction.Advances in genetics · 2014Review
- Mechanisms of Candida biofilm drug resistance.Future microbiology · 2013Review
- Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.Eukaryotic cell · 2013Article
- Adhesins in human fungal pathogens: glue with plenty of stick.Eukaryotic cell · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To mate, MTL-homozygous strains of the yeast pathogen Candida albicans must switch from the white to opaque phase. Mating-competent opaque cells then release pheromone that induces polarization, a G1 block and conjugation tube formation in opaque cells of opposite mating type. Pheromone also induces mating-incompetent white cells to become adhesive and cohesive, and form thicker biofilms that facilitate mating. The pheromone response pathway of white cells shares the upstream components of that of opaque cells, but targets a different transcription factor. Here we demonstrate that the genes up-regulated by the pheromone in white cells are activated through a common cis-acting sequence, WPRE, which is distinct from the cis-acting sequence, OPRE, responsible for up-regulation in opaque cells. Furthermore, we find that these white-specific genes play roles in white cell biofilm formation, and are essential for biofilm formation in the absence of an added source of pheromone, suggesting either an autocrine or pheromone-independent mechanism. These results suggest an intimate, complex and unique relationship between switching, mating and MTL-homozygous white cell biofilm formation, the latter a presumed virulence factor in C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.