ArticlePloS one2009
Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP).Obesity (Silver Spring, Md.) · 2012Trial
- Restoring STAR*D: A RIAT Reanalysis of Medication Augmentation Therapy After Failed SSRI Treatment Using Patient-Level Data with Fidelity to the Original Research Protocol.medRxiv : the preprint server for health sciences · 2025Article
- Restoring STAR*D: A Reanalysis of Drug-Switch Therapy After Failed SSRI Treatment Using Patient-Level Data with Fidelity to the Original STAR*D Research Protocol.medRxiv : the preprint server for health sciences · 2025Article
- Behavioral and social predictors of suicidal ideation and attempts among adolescents and young adults.PLOS mental health · 2025Article
- Prediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models.Drug and alcohol dependence · 2024Article
- Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- DeepBiomarker: Identifying Important Lab Tests from Electronic Medical Records for the Prediction of Suicide-Related Events among PTSD Patients.Journal of personalized medicine · 2022Article
- Using Administrative Data to Predict Suicide After Psychiatric Hospitalization in the Veterans Health Administration System.Frontiers in psychiatry · 2020Article
- A Drug Safety Rating System Based on Postmarketing Costs Associated with Adverse Events and Patient Outcomes.Journal of managed care & specialty pharmacy · 2015Article
- Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011.BMC pharmacology & toxicology · 2014Article
- Article
- Doxycycline and suicidality.BMJ case reports · 2013Article
- Associations between Overall and Abdominal Obesity and Suicidal Ideation among US Adult Women.Journal of obesity · 2012Article
- Regional and temporal variations in coding of hospital diagnoses referring to upper gastrointestinal and oesophageal bleeding in Germany.BMC health services research · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
contextIn randomized controlled trials (RCTs), some drugs, including CB1 antagonists for obesity treatment, have been shown to cause increased suicidal ideation. A key question is whether drugs that increase or are associated with increased suicidal ideations are also associated with suicidal behavior, or whether drug-induced suicidal ideations are unlinked epiphenomena that do not presage the more troubling and potentially irrevocable outcome of suicidal behavior. This is difficult to determine in RCTs because of the rarity of suicidal attempts and completions.
objectiveTo determine whether drugs associated with more suicidal ideations are also associated with more suicide attempts in large spontaneous adverse event (AE) report databases. METHODOLOGY: Generalized linear models with negative binomial distribution were fitted to Food and Drug Administration (FDA) Adverse Event (AE) Reporting System (AERS) data from 2004 to 2008. A total of 1,404,470 AEs from 832 drugs were analyzed as a function of reports of suicidal ideations; other non-suicidal adverse reactions; drug class; proportion of reports from males; and average age of subject for which AE was filed. Drug was treated as the unit of analysis, thus the statistical models effectively had 832 observations.
main outcome measuresReported suicide attempts and completed suicides per drug.
results832 drugs, ranging from abacavir to zopiclone, were evaluated. The 832 drugs, as primary suspect drugs in a given adverse event, accounted for over 99.9% of recorded AERS. Suicidal ideations had a significant positive association with suicide attempts (p<.0001) and had an approximately 131-fold stronger magnitude of association than non-suicidal AERs, after adjusting for drug class, gender, and age.
conclusionsIn AE reports, drugs that are associated with increased suicidal ideations are also associated with increased suicidal attempts or completions. This association suggests that drug-induced suicidal ideations observed in RCTs plausibly represent harbingers that presage the more serious suicide attempts and completions and should be a cause for concern.
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