ArticleAJNR. American journal of neuroradiology2010
In vivo proton MR spectroscopy evaluation of pyogenic brain abscesses: a report of 194 cases.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 97 citations in OpenAlex.
- A systematic approach to MR spectroscopy of the brain: Indications, protocol, metabolites, and spectral analysis in neurologic diseases.The neuroradiology journal · 2026Review
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- Brain Abscess Mimicking Brain Tumors: A Systematic Review of Individual Patient's Data.Asian journal of neurosurgery · 2025Article
- Proton Magnetic Resonance Spectroscopy of the Developing Human Brain.Clinical neuroimaging (Hoboken, N.J.) · 2025Article
- Clinical utility of MR spectroscopy for gynecological pelvic abscesses using next-generation sequencing technology for the detection of causative bacteria.Experimental and therapeutic medicine · 2023Article
- Neuroimaging Patterns of Intracranial Infections: Meningitis, Cerebritis, and Their Complications.Neuroimaging clinics of North America · 2023Review
- Insights into Magnetic Resonance Imaging Findings in Central Nervous System Paracoccidioidomycosis: A Comprehensive Review.Research and reports in tropical medicine · 2023Review
- Proton MR Spectroscopy of Pediatric Brain Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Hypertensive emergency and seizures during haemodialysis.BMJ case reports · 2021Article
- Deuterium Metabolic Imaging-Rediscovery of a Spectroscopic Tool.Metabolites · 2021Review
- Clinical Applications of Magnetic Resonance Spectroscopy in Brain Tumors: From Diagnosis to Treatment.Radiologic clinics of North America · 2021Review
- MR spectroscopy in pediatric neuroradiology.Translational pediatrics · 2021Review
- A clinical case report of brain abscess caused by Nocardia brasiliensis in a non-immunocompromised patient and a relevant literature review.BMC infectious diseases · 2020Review
- Brain abscess in pediatric age: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Brain Abscess Showing a Lack of Restricted Diffusion and Successfully Treated with Linezolid.Brain tumor research and treatment · 2018Article
- A Clinical Report of Two Cases of Cryptogenic Brain Abscess and a Relevant Literature Review.Frontiers in neuroscience · 2018Article
- Brain Abscess in a Patient with Rendu-Osler-Weber Syndrome: Value of Proton Magnetic Resonance Spectroscopy.NMC case report journal · 2016Article
- Atypical pyogenic brain abscess evaluation by diffusion-weighted imaging: diagnosis with multimodality MR imaging.Japanese journal of radiology · 2015Article
- Multimodality Brain Tumor Imaging: MR Imaging, PET, and PET/MR Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Review
- Neonatal deep white matter venous infarction and liquefaction: a pseudo-abscess lesion.Pediatric radiology · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe combination of nonspecific clinical findings and similarities in morphologic appearances on imaging often makes it difficult to distinguish abscesses from other brain lesions. We present a retrospective analysis of in vivo (1)H-MR spectroscopy data for characterization of the etiology of the brain abscess based on the established criteria and demonstrate the sensitivity and specificity of metabolite markers assigned to specific bacterial groups defined by the microbial culture in 194 patients. MATERIALS AND
methodsConventional MR imaging and in vivo (1)H-MR spectroscopy data were evaluated from patients with pyogenic brain abscesses, with ages ranging from 3 to 60 years. Imaging and (1)H-MR spectroscopy were performed on a 1.5T scanner. After MR imaging was performed and analyzed, pus aspirates were obtained in all patients. The causative organisms were confirmed by pus cultures.
resultsResonance of AAs with or without other metabolites on in vivo (1)H-MR spectroscopy was observed in 80% of abscesses, with a sensitivity and specificity of 0.72 and 0.30, respectively. Most obligate anaerobes and some facultative anaerobes showed the presence of Lac/Lip, AAs, and Ac with or without Suc. Mostly obligate aerobes or facultative anaerobes showed the presence of Lac and AAs, with or without lipids.
conclusionsThe presence of AAs on in vivo (1)H-MR spectroscopy is a sensitive marker of pyogenic abscess, but its absence does not rule out a pyogenic etiology. The presence of Ac with or without Suc favors an anaerobic bacterial origin of the abscess; however, this may also be seen in some of the abscesses secondary to facultative anaerobes.
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