ArticleGenes & development2009
Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026Article
- Sex-specific transcriptome dynamics ofGenes & development · 2025Article
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- Sequence reliance of abioRxiv : the preprint server for biology · 2023Article
- Article
- Review
- Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes.Chromosoma · 2020Article
- Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.Molecular and cellular biology · 2017Article
- Article
- Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.Genetics · 2016Review
- Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.Journal of genetics · 2015Review
- Dosage compensation in Drosophila.Cold Spring Harbor perspectives in biology · 2015Review
- Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly.PloS one · 2015Article
- Mechanisms of x chromosome dosage compensation.Journal of genomics · 2015Review
- Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.Genes & development · 2014Article
- A new player in X identification: the CLAMP protein is a key factor in Drosophila dosage compensation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Arpeggio: harmonic compression of ChIP-seq data reveals protein-chromatin interaction signatures.Nucleic acids research · 2013Article
- Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.Nature structural & molecular biology · 2013Article
- Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster.Nucleic acids research · 2012Article
- Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription.Nature reviews. Genetics · 2012Review
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Authors and funding
5 authors.
Funding
Abstract
Dosage compensation in Drosophila melanogaster males is achieved via targeting of male-specific lethal (MSL) complex to X-linked genes. This is proposed to involve sequence-specific recognition of the X at approximately 150-300 chromatin entry sites, and subsequent spreading to active genes. Here we ask whether the spreading step requires transcription and is sequence-independent. We find that MSL complex binds, acetylates, and up-regulates autosomal genes inserted on X, but only if transcriptionally active. We conclude that a long-sought specific DNA sequence within X-linked genes is not obligatory for MSL binding. Instead, linkage and transcription play the pivotal roles in MSL targeting irrespective of gene origin and DNA sequence.
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