ArticleInvestigative ophthalmology & visual science2010
RGS7 and -11 complexes accelerate the ON-bipolar cell light response.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Parallel and convergent evolution in genes underlying seasonal migration.Evolution letters · 2025Article
- Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses.Scientific reports · 2021Article
- Arginylation Regulates G-protein Signaling in the Retina.Frontiers in cell and developmental biology · 2021Article
- Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.Cell reports · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.The European journal of neuroscience · 2016Article
- Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.The Journal of clinical investigation · 2015Article
- The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.The Journal of biological chemistry · 2015Article
- Article
- G protein signaling in the retina and beyond: the Cogan lecture.Investigative ophthalmology & visual science · 2014Article
- Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision.The Journal of biological chemistry · 2014Article
- GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mouse b-wave mutants.Documenta ophthalmologica. Advances in ophthalmology · 2014Review
- Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.Investigative ophthalmology & visual science · 2013Article
- An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.PloS one · 2013Article
- Article
- "mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling.Wiley interdisciplinary reviews. Membrane transport and signaling · 2012Article
- Gβ3 is required for normal light ON responses and synaptic maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe retinal ON-bipolar cell (ON-BPC) light response is initiated upon deactivation of the metabotropic glutamate receptor mGluR6 and the G protein Go. G protein-based signaling cascades are typically accelerated by interaction of the G protein alpha subunit with a member of the regulator of G protein signaling (RGS) protein family. The goal of this study was to determine whether RGS7 and/or -11 serve this function in retinal ON-BPCs.
methodsRetinas from mice lacking RGS11 (RGS11(-/-)), or with a deletion mutation in RGS7 (RGS7(Delta/Delta)), or both, were compared to wild-type (WT) by immunofluorescence confocal microscopy. The retinal light response was measured with the electroretinogram (ERG). The kinetics of simulated light responses from individual rod bipolar cells were recorded by whole-cell patch-clamp electrophysiology.
resultsLevels of the R7 RGS interaction partners, Gbeta5 and R9AP, were reduced in the outer plexiform layer of the RGS11(-/-) and RGS7(Delta/Delta)/RGS11(-/-) mice. ERG recordings demonstrated a delay in the rising phase of the ERG b-wave, larger photopic b-wave amplitudes, and increased scotopic threshold response sensitivity in the RGS11(-/-) and RGS7(Delta/Delta)/RGS11(-/-) mice. The ERG measured from the RGS7(Delta/Delta) retina was normal. Patch-clamp recordings of chemically simulated light responses of rod BPCs revealed a 25-ms delay in the onset of the ON-BPC response in the RGS7(Delta/Delta)/RGS11(-/-) mouse compared with the WT.
conclusionsRGS11 plays a role in the deactivation of Galphao, which precedes activation of the depolarizing current in ON-BPCs. RGS7 must also serve a role as changes in RGS7(Delta/Delta)/RGS11(-/-) mice were greater than those in RGS11(-/-) mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.