ArticleAmerican journal of respiratory and critical care medicine2009
Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validity and Cost-effectiveness Analysis of a Home Respiratory Polygraphy for the Diagnosis of Obstructive Sleep Apnea in Children (DINISAS)
Metabolomics of Obstructive Sleep Apnea
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Proteomic Insights into Childhood Obesity: A Systematic Review of Protein Biomarkers and Advances.International journal of molecular sciences · 2025Pooled it
- Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Assessing the association between multiple indicators of inflammation and sleep disorders in young and middle-aged women: insights from traditional and machine learning approaches.European journal of medical research · 2025Article
- Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography.Children (Basel, Switzerland) · 2023Review
- Circulating levels of urocortin neuropeptides are impaired in children with overweight.Obesity (Silver Spring, Md.) · 2022Article
- Article
- Serum Proteomic Analysis by Tandem Mass Tag-Based Quantitative Proteomics in Pediatric Obstructive Sleep Apnea.Frontiers in molecular biosciences · 2022Article
- Urine 5-Eicosatetraenoic Acids as Diagnostic Markers for Obstructive Sleep Apnea.Antioxidants (Basel, Switzerland) · 2021Article
- Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes.Scientific reports · 2021Article
- Coagulation and Fibrinolysis in Obstructive Sleep Apnoea.International journal of molecular sciences · 2021Review
- Validity and Cost-Effectiveness of Pediatric Home Respiratory Polygraphy for the Diagnosis of Obstructive Sleep Apnea in Children: Rationale, Study Design, and Methodology.Methods and protocols · 2021Article
- Measurement of upper airway resistances: A simple way to assess its collapsibility?Sleep & breathing = Schlaf & Atmung · 2020Observational
- A review of the "OMICS" for management of patients with obstructive sleep apnoea.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020Review
- Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art.International journal of environmental research and public health · 2019Review
- Effect of semi-rapid maxillary expansion in children with obstructive sleep apnea syndrome: 5-month follow-up study.Sleep & breathing = Schlaf & Atmung · 2018Article
- DNA Methylation in Pediatric Obstructive Sleep Apnea: An Overview of Preliminary Findings.Frontiers in pediatrics · 2018Review
- Machines Learning to Detect Obstructive Sleep Apnea in Children. Are We There Yet?American journal of respiratory and critical care medicine · 2017Article
- P4 medicine approach to obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2017Review
- Urinary biomarkers and obstructive sleep apnea in patients with Down syndrome.Sleep medicine · 2017Article
- A predictive model for obstructive sleep apnea and Down syndrome.American journal of medical genetics. Part A · 2017Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleSleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children.
objectivesTo examine whether the urinary proteome uncovers specific clusters that are differentially expressed in the urine of children with OSA.
methodsTwo-dimensional differential in-gel electrophoresis (2D-DIGE) and mass spectrometry proteomics followed by validation with western blot of ELISA. MEASUREMENTS AND MAIN
resultsMorning urine proteins from 60 children with polysomnographically confirmed OSA and from matched children with primary snoring (n = 30) and control subjects (n = 30) were assessed. A total of 16 proteins that are differentially expressed in OSA were identified, and 7 were confirmed by either immunoblots or ELISA. Among the latter, receiver-operator curve analyses of urinary concentrations of uromodulin, urocortin-3, orosomucoid-1, and kallikrein assigned favorable predictive properties to these proteins. Furthermore, combinatorial approaches indicated that the presence of values beyond the calculated cutoff concentrations for three or more of the proteins yielded a sensitivity of 95% and a specificity of 100%.
conclusionsProteomic approaches reveal that pediatric OSA is associated with specific and consistent alterations in urinary concentrations of specific protein clusters. Future studies aiming to validate this approach as a screening method of habitually snoring children appears warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.