ArticleGenetics2009
Exact tests for Hardy-Weinberg proportions.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
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- Short tandem repeat (STR) variation from 6 cities in Iraq based on 15 loci.Journal, genetic engineering & biotechnology · 2023Article
- Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.BMC genomics · 2023Observational
- Mutation Load in Sunflower Inversions Is Negatively Correlated with Inversion Heterozygosity.Molecular biology and evolution · 2022Article
- Reproductive Biology of the Sea CucumberBiology · 2022Article
- Asymptotic tests for Hardy-Weinberg equilibrium in hexaploids.Horticulture research · 2022Article
- A network algorithm for the X chromosomal exact test for Hardy-Weinberg equilibrium with multiple alleles.Molecular ecology resources · 2021Article
- Rapid genetic adaptation to recently colonized environments is driven by genes underlying life history traits.BMC genomics · 2021Article
- Incipient resistance to an effective pesticide results from genetic adaptation and the canalization of gene expression.Evolutionary applications · 2021Article
- Genetic and demographic history define a conservation strategy for earth's most endangered pinniped, the Mediterranean monk seal Monachus monachus.Scientific reports · 2021Article
- Contrasting Phylogeographic Patterns inFrontiers in plant science · 2021Article
- The Interplay Between Prenatal Adversity, Offspring Dopaminergic Genes, and Early Parenting on Toddler Attentional Function.Frontiers in behavioral neuroscience · 2021Article
- Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany.International journal for parasitology. Drugs and drug resistance · 2020Article
- Validating a predictive model of cannabinoid inheritance with feral, clinical, and industrial Cannabis sativa.American journal of botany · 2020Article
- Connectivity and population structure of albacore tuna across southeast Atlantic and southwest Indian Oceans inferred from multidisciplinary methodology.Scientific reports · 2020Article
- Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand.Cognitive, affective & behavioral neuroscience · 2020Article
- Risk assessment of trihalomethanes exposure by consumption of IV gamma products: Evidences from a Portuguese regional survey.Toxicology reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Exact conditional tests are often required to evaluate statistically whether a sample of diploids comes from a population with Hardy-Weinberg proportions or to confirm the accuracy of genotype assignments. This requirement is especially common when the sample includes multiple alleles and sparse data, thus rendering asymptotic methods, such as the common chi(2)-test, unreliable. Such an exact test can be performed using the likelihood ratio as its test statistic rather than the more commonly used probability test. Conceptual advantages in using the likelihood ratio are discussed. A substantially improved algorithm is described to permit the performance of a full-enumeration exact test on sample sizes that are too large for previous methods. An improved Monte Carlo algorithm is also proposed for samples that preclude full enumeration. These algorithms are about two orders of magnitude faster than those currently in use. Finally, methods are derived to compute the number of possible samples with a given set of allele counts, a useful quantity for evaluating the feasibility of the full enumeration procedure. Software implementing these methods, ExactoHW, is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.