ArticleTrends in genetics : TIG2009
Processed pseudogenes: the 'fossilized footprints' of past gene expression.
Article in Trends in genetics : TIG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Interchromosomal Colocalization with Parental Genes Is Linked to the Function and Evolution of Mammalian Retrocopies.Molecular biology and evolution · 2023Article
- Pseudogenes in Cancer: State of the Art.Cancers · 2023Review
- Evolution and function of developmentally dynamic pseudogenes in mammals.Genome biology · 2022Article
- Higher Rates of Processed Pseudogene Acquisition in Humans and Three Great Apes Revealed by Long-Read Assemblies.Molecular biology and evolution · 2021Article
- Structural characterization and duplication modes of pseudogenes in plants.Scientific reports · 2021Article
- Pseudogenes and Their Genome-Wide Prediction in Plants.International journal of molecular sciences · 2016Review
- The life history of retrocopies illuminates the evolution of new mammalian genes.Genome research · 2016Article
- Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.International journal of molecular sciences · 2015Review
- Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss.BMC biology · 2013Article
- Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.Genome research · 2012Article
- On the quest for selective constraints shaping the expressivity of the genes casting retropseudogenes in human.BMC genomics · 2011Article
- Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates.BMC evolutionary biology · 2011Article
- The Wolbachia endosymbiont as an anti-filarial nematode target.Symbiosis (Philadelphia, Pa.) · 2010Article
- Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer.PloS one · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although our knowledge of the genes and genomes of extinct organisms is improving as a result of progress in sequencing ancient DNA, the transcriptomes of extinct organisms remain inaccessible, owing to the rapid degradation of messenger RNA after death. We provide empirical evidence that gene expression levels in the reproductive tissues of mice and during early mouse development correlate highly with the rate of inherited retroposition: the source of processed pseudogenes in the genome. Thus, processed pseudogenes might serve as fossilized footprints of the expression of their parent genes, shedding light on ancient transcriptomes that could provide significant insights into the evolution of gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.