ArticleBrain, behavior, and immunity2010
Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.
Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis.Brain, behavior, and immunity · 2018Pooled it
- Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Pooled it
- Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder.Journal of affective disorders · 2017Trial
- Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents.Brain, behavior, & immunity - health · 2022Article
- Sense of purpose in life and inflammation in healthy older adults: A longitudinal study.Psychoneuroendocrinology · 2022Article
- C-Reactive Protein as a Biomarker for Major Depressive Disorder?International journal of molecular sciences · 2022Review
- Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression.Journal of inflammation research · 2022Article
- C-reactive protein concentration in bipolar disorder: association with genetic variants.International journal of bipolar disorders · 2019Article
- C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy.Psychiatry investigation · 2019Article
- Multidimensional assessment of impulsivity-related measures in relation to externalizing behaviors.Psychological medicine · 2019Article
- Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect.Molecular neurobiology · 2019Review
- Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey.Scientific reports · 2019Article
- Higher Serum C Reactive Protein Determined C Reactive Protein Single-Nucleotide Polymorphisms Are Involved in Inherited Depression.Psychiatry investigation · 2018Article
- Association between CRP genetic diversity and bipolar disorder comorbid complications.International journal of bipolar disorders · 2018Article
- Depression is Associated with CRP SNPs in Patients with Family History.Translational neuroscience · 2017Article
- OXTR polymorphism predicts social relationships through its effects on social temperament.Social cognitive and affective neuroscience · 2015Article
- Child maltreatment, inflammation, and internalizing symptoms: Investigating the roles of C-reactive protein, gene variation, and neuroendocrine regulation.Development and psychopathology · 2015Article
- C-reactive protein gene variants: independent association with late-life depression and circulating protein levels.Translational psychiatry · 2015Article
- Mind and body: how the health of the body impacts on neuropsychiatry.Frontiers in pharmacology · 2013Review
- The vascular depression hypothesis: mechanisms linking vascular disease with depression.Molecular psychiatry · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although many studies have found psychological depression associated with higher circulating levels of C-reactive protein (CRP), not all findings are consistent. Since DNA sequence variation in the CRP gene has also been shown to predict plasma CRP levels, we hypothesized that plasma CRP may covary with depressive symptomatology as a function of allelic variation in the CRP gene. We tested this hypothesis in 868 healthy community volunteers of European ancestry. Depressive symptomatology was measured using the Center for Epidemiological Studies-Depression (CESD) scale, and plasma CRP was assayed from whole blood. Three polymorphisms [rs1417938 (A/T), rs1800947 (C/G) and rs1205 (C/T)] were genotyped and three-locus haplotypes were generated. Regression models adjusting for demographic and lifestyle-related covariates showed no direct association of CESD depression scores with CRP. In regression models adjusting for age, gender, education, smoking status and statin use, one CRP haplotype (T-G-C) was associated with CRP level (p=0.014) and a second haplotype (A-G-T) showed marginal association (p=0.064, respectively). Neither haplotype was related to depressive symptoms. However, plasma CRP was predicted by the interaction of A-G-T haplotype with depressive symptomatology (p=0.009). Higher CESD scores were associated positively with CRP levels among individuals with the A-G-T haplotype (p=0.004). In secondary analyses, body mass index was found to partially account for the moderating effects of the A-G-T haplotype on the association of depression with circulating CRP. In conclusion, we found that haplotypic variation in the CRP locus moderates an association of depressive symptoms with circulating CRP, which is partially mediated by BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.